Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer Wu-Wei Lai, MD, Fen-Fen Chen, MD,

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Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer Wu-Wei Lai, MD, Fen-Fen Chen, MD, Ming-Ho Wu, MD, Nan-Haw Chow, MD, Wu-Chou Su, MD, Mi-Chia Ma, PhD, Pei-Fang Su, MS, Helen Chen, MD, Mu-Yen Lin, MD, Yau-Lin Tseng, MD The Annals of Thoracic Surgery Volume 72, Issue 6, Pages 1868-1876 (December 2001) DOI: 10.1016/S0003-4975(01)03207-6

Fig 1 Analyses of traditional pathologic factors for recurrence in 73 patients with stage I non-small cell lung carcinoma by log-rank test and Cox univariate analysis model. (A) Angiolymphatic tumor emboli (Angio.), (B) tumor differentiation (well-differentiated [WD] versus non-well-differentiated), (C) histology (squamous cell carcinoma versus non-squamous cell carcinoma), (D) substage (IA versus IB). The Annals of Thoracic Surgery 2001 72, 1868-1876DOI: (10.1016/S0003-4975(01)03207-6)

Fig 2 Analyses of prognostic value of each epidermal growth factor receptor family members for recurrence in 73 patients with stage I non-small-cell lung carcinoma by log-rank test and Cox univariate analysis model. (A) ErbB-1. (B) ErbB-2. (C) ErbB-3. (D) ErbB-4. The Annals of Thoracic Surgery 2001 72, 1868-1876DOI: (10.1016/S0003-4975(01)03207-6)

Fig 3 (A) Expression patterns of epidermal growth factor receptor family members in 73 patients with stage I non-small-cell lung carcinoma. (B) Graph of number of epidermal growth factor receptor family members expressed in the 73 patients. The Annals of Thoracic Surgery 2001 72, 1868-1876DOI: (10.1016/S0003-4975(01)03207-6)

Fig 4 Kaplan-Meier recurrence-free survival estimates stratified by (A) combined ErbB-1+, -3+, (B) expression of three or more members of epidermal growth factor receptor family, (C) expression of ErbB-1+, -2+, -3+ or ErbB-1+, -3+, -4+. Difference between curves was analyzed by log-rank test and Cox univariate analysis. The Annals of Thoracic Surgery 2001 72, 1868-1876DOI: (10.1016/S0003-4975(01)03207-6)