Superantigens, Autoantigens, and Pathogenic T Cells in Psoriasis

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Superantigens, Autoantigens, and Pathogenic T Cells in Psoriasis Brian J. Nickoloff, Tamara Wrone-Smith Journal of Investigative Dermatology Volume 110, Issue 4, Pages 459-460 (April 1998) DOI: 10.1046/j.1523-1747.1998.00158.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 CD69 expression detected on lymphocytes near basal epidermal keratinocytes in a psoriatic plaque (PP skin) converted from symptomless (PN) skin. The human PN skin was grafted onto a SCID mouse, and injected intradermally with an autologous CD4+ T cell line as described in the text. A biopsy of the skin lesion created was processed for frozen section immunohistology using anti-CD69 monoclonal antibody (Becton-Dickenson, Mountain View, CA), avidin-biotin staining (Vectastain Kit, Vector Labs, Burlington, CA), with 3-amino-4-ethylcarbazole producing a positive red reactive product. Scale bar, 10 μm. Journal of Investigative Dermatology 1998 110, 459-460DOI: (10.1046/j.1523-1747.1998.00158.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions