Nanobacteria: An infectious cause for kidney stone formation

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Presentation transcript:

Nanobacteria: An infectious cause for kidney stone formation Neva Çiftçioglu, Dr, Mikael Björklund, Kai Kuorikoski, Kim Bergström, E. Olavi Kajander Kidney International Volume 56, Issue 5, Pages 1893-1898 (November 1999) DOI: 10.1046/j.1523-1755.1999.00755.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 (a) Scanning electron microscopic (SEM) observation of calcified nanobacteria cultured in serum-free condition. (b) Detail from fractured nanobacteria showing mineral formation as layers shown by arrows. (c) SEM image of human apatite kidney stone showing apatite units. (d) Immunofluorescent (IF) staining of the nanobacteria similar to those shown in (a), and (e) the kidney stone shown in (c) with an anti-nanobacteria monoclonal antibody. Bars: a and c, 10 μm; b, 1 μm. Kidney International 1999 56, 1893-1898DOI: (10.1046/j.1523-1755.1999.00755.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 (a) Immunofluorescent (IF) staining of demineralized nanobacteria. (b) Double staining of 3T6 cells infected with nanobacteria cultured from a kidney stone. (b) IF staining. (c) DNA staining. (d) Control IF staining of noninfected cells. Kidney International 1999 56, 1893-1898DOI: (10.1046/j.1523-1755.1999.00755.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Biomineralization of Ca (a) and incorporation of 85Sr (b) by the nanobacteria isolates of human kidney stones and by the controls. Altogether, 46 of the 50 stones analyzed indicated incorporation. Data from two representative nanobacterial isolates from each major type of kidney stone are shown. Kidney International 1999 56, 1893-1898DOI: (10.1046/j.1523-1755.1999.00755.x) Copyright © 1999 International Society of Nephrology Terms and Conditions