David M. Charytan, John P. Forman Kidney International

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Presentation transcript:

You are what you eat: dietary salt intake and renin–angiotensin blockade in diabetic nephropathy David M. Charytan, John P. Forman Kidney International Volume 82, Issue 3, Pages 257-259 (August 2012) DOI: 10.1038/ki.2012.148 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Multifactorial role of sodium in the renin–angiotensin system. Sodium loading typically suppresses renin synthesis, but this response may be attenuated in diabetes. Conversely, sodium loading can directly activate mineralocorticoid receptor activity via upregulation of Rac-1 signaling or via increases in angiotensin-converting enzyme (ACE) activity. Kidney International 2012 82, 257-259DOI: (10.1038/ki.2012.148) Copyright © 2012 International Society of Nephrology Terms and Conditions