Volume 44, Issue 4, Pages (April 2006)

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Volume 44, Issue 4, Pages 829-831 (April 2006) Liver transplantation in an adult with sclerosing cholangitis due to Langerhans cell histiocytosis William Griffiths, Susan Davies, Paul Gibbs, Andrew Thillainayagam, Graeme Alexander Journal of Hepatology Volume 44, Issue 4, Pages 829-831 (April 2006) DOI: 10.1016/j.jhep.2005.12.024 Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Endoscopic retrograde cholangiopancreatography (ERCP) showing appearances consistent with extensive sclerosing cholangitis. Journal of Hepatology 2006 44, 829-831DOI: (10.1016/j.jhep.2005.12.024) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Macroscopic appearance of explanted liver. The organ has mottled bile-stained discolouration due to severe cholestasis but a smooth non-cirrhotic capsular surface. Journal of Hepatology 2006 44, 829-831DOI: (10.1016/j.jhep.2005.12.024) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Infiltration by Langerhans cells. Panel A shows a massively expanded portal tract with a cellular infiltrate and marginal ductular proliferation. Pre-existing portal structures are shown (arrow) (H–E ×40). The infiltrate (B) consists of eosinophils and large mononuclear cells with cleaved nuclei (H–E ×400). These cells are positive for CD1a (C) consistent with Langerhans cells (×200). Journal of Hepatology 2006 44, 829-831DOI: (10.1016/j.jhep.2005.12.024) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

Fig. 4 Focal liver abnormalities. Panel A shows sub capsular infiltrates of S100-positive (Langerhans) cells (×20). Florid ductular proliferation is seen in a portal tract (B) with bile plugging in the parenchyma (arrows) (H–E ×100). Ductopenia is evident in other portal tracts (C) (A, artery, V, vein, H–E ×400). In panel D, a major interlobar bile duct is seen infiltrated by CD1a-positive Langerhans cells (×200). Journal of Hepatology 2006 44, 829-831DOI: (10.1016/j.jhep.2005.12.024) Copyright © 2006 European Association for the Study of the Liver Terms and Conditions