Michael P. Epstein, Xihong Lin, Michael Boehnke

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A Tobit Variance-Component Method for Linkage Analysis of Censored Trait Data Michael P. Epstein, Xihong Lin, Michael Boehnke The American Journal of Human Genetics Volume 72, Issue 3, Pages 611-620 (March 2003) DOI: 10.1086/367924 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Example of censoring for a normally distributed trait. Latent trait values truly less than y* are observed at y*. The American Journal of Human Genetics 2003 72, 611-620DOI: (10.1086/367924) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 VC analyses of HDLR on chromosome 2. For the tobit method, the maximum likelihood-ratio statistic is 9.1 (maximum LOD score 1.98), at 58 cM; for the traditional method, the maximum likelihood-ratio statistic is 5.7 (maximum LOD score 1.24), at 60 cM. The American Journal of Human Genetics 2003 72, 611-620DOI: (10.1086/367924) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 3 VC analyses of TG on chromosome 20. For the tobit method, the maximum likelihood-ratio statistic is 2.2 (maximum LOD score 0.48), at 85 cM; for the traditional method, the maximum likelihood-ratio statistic is 8.0 (maximum LOD score 1.74), at 84 cM. The American Journal of Human Genetics 2003 72, 611-620DOI: (10.1086/367924) Copyright © 2003 The American Society of Human Genetics Terms and Conditions