The management of CKD: A look into the future

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Presentation transcript:

The management of CKD: A look into the future A. Khwaja, M. El Kossi, J. Floege, M. El Nahas Kidney International Volume 72, Issue 11, Pages 1316-1323 (December 2007) DOI: 10.1038/sj.ki.5002489 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 The cellular mechanisms underlying this fibrotic process are characterized by kidney cell loss through necrosis and apoptosis, EMT (reversal to an embryonic phenotype), and proliferation of myofibroblasts with subsequent increased ECM synthesis along with decreased breakdown and clearance of ECM. Kidney International 2007 72, 1316-1323DOI: (10.1038/sj.ki.5002489) Copyright © 2007 International Society of Nephrology Terms and Conditions