Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization.

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Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells Yinchuan Xu, Xinyang Hu, Lihan Wang, Zhi Jiang, Xianbao Liu, Hong Yu, Zhaocai Zhang, Huiqiang Chen, Han Chen, Gustav Steinhoff, Jun Li, Jian'an Wang International Journal of Cardiology Volume 168, Issue 4, Pages 4551-4554 (October 2013) DOI: 10.1016/j.ijcard.2013.06.087 Copyright © 2013 Terms and Conditions

Fig. 1 Effect of AT2R stimulation on migration of BMMNCs in vitro. A–H. The migratory ability of BMMNCs was determined by transwell study in vitro. BMMNCs were pre-incubated with DMEM, CGP42112A±U0126, CGP42112A±L-NAME, AngII+Valsartan±U0126, AngII+Valsartan±L-NAME, or AngII+Valsartan+PD123319. Bar=100μm. Blue dots represented for the BMMNCs migrated into the lower chamber of transwell system. I. Quantification of BMMNCs migrated into the lower chamber. HPF: high power field. n=6 for each group, *P<0.01 versus all other groups. International Journal of Cardiology 2013 168, 4551-4554DOI: (10.1016/j.ijcard.2013.06.087) Copyright © 2013 Terms and Conditions

Fig. 2 AT2R stimulation enhanced BMMNCs homing to ischemic myocardium in vivo. Donor BMMNCs derived from males rats were injected into female rats via tail vein. 3days after injection, copy number of sry gene in ischemic and non-ischemic region of heart tissue were determined by real-time PCR, respectively. n=3 for each group. ND not detected. *P<0.05 versus BMMNC group, and #P<0.05 versus BMMNCs+AngII+Valsartan+PD123319 group. International Journal of Cardiology 2013 168, 4551-4554DOI: (10.1016/j.ijcard.2013.06.087) Copyright © 2013 Terms and Conditions

Fig. 3 Intravenous transplantation of AT2R stimulated BMMNCs improved cardiac function and reduced infarct size. A. Representative M-mode echocardiograms of each group. 1. Sham group; 2. DMEM group; 3. BMMNCs group; 4. BMMNCs+AngII+Valsartan group; 5. BMMNCs+CGP42112A group; 6. BMMNCs+AngII+Valsartan+PD123319 group. B. Left ventricular ejection fraction. C. Fraction shortening. Sham n=5; DMEM group n=9; BMMNCs group n=9; BMMNCs+Ang II+Valsartan group n=9; BMMNCs+CGP42112A group n=9; and BMMNCs+AngII+Valsartan+PD123319 group n=7. *P<0.05 versus BMMNCs group, and #P<0.05 versus BMMNCs+AngII+Valsartan+PD123319 group. D. Infarct size was measured by Masson trichrome staining of heart tissue sections from each group. DMEM group n=5, BMMNCs group n=6, BMMNCs+AngII+Valsartan group n=5, BMMNCs+CGP42112A group n=6, and BMMNCs+AngII+Valsartan+PD123319 group n=4. *P<0.05 versus BMMNCs group, #P<0.05 versus BMMNCs+AngII+Valsartan+PD123319 group. International Journal of Cardiology 2013 168, 4551-4554DOI: (10.1016/j.ijcard.2013.06.087) Copyright © 2013 Terms and Conditions