Martin J. MacInnis, BSc, Sarah Koch, MSc, Kristin E

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Presentation transcript:

Acute Mountain Sickness Is Not Repeatable Across Two 12-Hour Normobaric Hypoxia Exposures Martin J. MacInnis, BSc, Sarah Koch, MSc, Kristin E. MacLeod, BSc, Eric A. Carter, MSc, Radha Jain, BSc, Michael S. Koehle, MD, PhD, Jim L. Rupert, PhD Wilderness & Environmental Medicine Volume 25, Issue 2, Pages 143-151 (June 2014) DOI: 10.1016/j.wem.2013.11.007 Copyright © 2014 Wilderness Medical Society Terms and Conditions

Figure 1 The Lake Louise score at hour 0 (open bars) and hour 12 (solid bars) of the sham, first hypoxic, and second hypoxic exposures (PIO2 was 132mmHg, 90mmHg, and 90mmHg, respectively). *Denotes a 12-hour mean that was significantly greater than the 0-hour mean of the same condition (P < .05). †Denotes a 12-hour mean that was significantly greater than the 12-hour sham mean (P < .05). §Denotes a 12-hour mean that was significantly greater than the 12-hour mean of the second hypoxia exposure (P < .05). Error bars represent 1 SD of the mean, and n = 25. Wilderness & Environmental Medicine 2014 25, 143-151DOI: (10.1016/j.wem.2013.11.007) Copyright © 2014 Wilderness Medical Society Terms and Conditions

Figure 2 The mean Lake Louise score (left) and sleep difficulty item score (right) from hour 12 of sham conditions that randomly occurred on the first (n = 8), second (n = 8), or third (n = 9) exposure of the study. Error bars represent 1 SD of the mean. †Denotes a statistically significant linear trend for decreasing sleep difficulty scores (P = .025). The linear trend for the Lake Louise Score was not statistically significant (P = .066). Wilderness & Environmental Medicine 2014 25, 143-151DOI: (10.1016/j.wem.2013.11.007) Copyright © 2014 Wilderness Medical Society Terms and Conditions

Figure 3 Nocturnal oxygen saturation (Spo2) of subjects during the second hypoxic exposure. (A) The relationship between the mean Spo2 and the Lake Louise score on the second hypoxic exposure. (B) The percentage of time elapsed below thresholds of Spo2 for subjects with acute mountain sickness (AMS+ [open bars]) and subjects without acute mountain sickness (AMS− [solid bars]). Error bars represent 1 SD of the mean, and n = 25. Wilderness & Environmental Medicine 2014 25, 143-151DOI: (10.1016/j.wem.2013.11.007) Copyright © 2014 Wilderness Medical Society Terms and Conditions