Genetic Linkage of Autosomal-Dominant Alport Syndrome with Leukocyte Inclusions and Macrothrombocytopenia (Fechtner Syndrome) to Chromosome 22q11-13

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Genetic Linkage of Autosomal-Dominant Alport Syndrome with Leukocyte Inclusions and Macrothrombocytopenia (Fechtner Syndrome) to Chromosome 22q11-13 Amos Toren, Ninette Amariglio, Galit Rozenfeld-Granot, Amos J. Simon, Frida Brok-Simoni, Elon Pras, Gideon Rechavi The American Journal of Human Genetics Volume 65, Issue 6, Pages 1711-1717 (December 1999) DOI: 10.1086/302654 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree and typing for eight chromosome 22 markers. Circles represent females, and squares represent males; unblackened symbols denote unaffected individuals, and blackened symbols denote affected individuals. Critical recombinations in individuals II-5, III-5, III-11, IV-3, and IV-7 define a 4-2-4-4-2-5 haplotype that is coinherited with the disease and that is not shared by the unaffected family members. The American Journal of Human Genetics 1999 65, 1711-1717DOI: (10.1086/302654) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Schematic map of the interval containing the disease gene on chromosome 22. The markers are illustrated on the right. The American Journal of Human Genetics 1999 65, 1711-1717DOI: (10.1086/302654) Copyright © 1999 The American Society of Human Genetics Terms and Conditions