Immunosuppression in liver transplant recipients with renal impairment

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Immunosuppression in liver transplant recipients with renal impairment C. Duvoux, G.P. Pageaux  Journal of Hepatology  Volume 54, Issue 5, Pages 1041-1054 (May 2011) DOI: 10.1016/j.jhep.2010.12.001 Copyright © 2011 Terms and Conditions

Fig. 1 Probability of survival after liver transplantation according to dialysis in the early post transplant period (p=0.0001). Adapted from Singh et al. [12]. Journal of Hepatology 2011 54, 1041-1054DOI: (10.1016/j.jhep.2010.12.001) Copyright © 2011 Terms and Conditions

Fig. 2 Schematic representation of the pathophysiology of calcineurin inhibitors nephrotoxicity. Reprinted from Naesens et al. [45], with permission from the American Society of Nephrology. Journal of Hepatology 2011 54, 1041-1054DOI: (10.1016/j.jhep.2010.12.001) Copyright © 2011 Terms and Conditions

Fig. 3 Renal injury after liver transplantation. Role of calcineurin inhibitors and other co-factors. Journal of Hepatology 2011 54, 1041-1054DOI: (10.1016/j.jhep.2010.12.001) Copyright © 2011 Terms and Conditions

Fig. 4 Protection of the kidney in the early post-operative period: how to tailor immunosuppression to the individual profile of the LT recipient? ATG, anti-thymocytes globumins; CNI, calcineurin inhibitors; HRS, hepato-renal syndrome; LT, liver transplantation; MMF, mycophenolate mofetil. Journal of Hepatology 2011 54, 1041-1054DOI: (10.1016/j.jhep.2010.12.001) Copyright © 2011 Terms and Conditions

Fig. 5 Immunosuppressive strategies after liver transplantation: an algorithm for mid/long term kidney protection. CNI calcineurin inhibitors; GFR, glomerular filtration rate; MPA, mycophenolate acid. Journal of Hepatology 2011 54, 1041-1054DOI: (10.1016/j.jhep.2010.12.001) Copyright © 2011 Terms and Conditions

Journal of Hepatology 2011 54, 1041-1054DOI: (10. 1016/j. jhep. 2010 Copyright © 2011 Terms and Conditions