Progression of fibrosis in chronic hepatitis C Marc G. Ghany, David E. Kleiner, Harvey Alter, Edward Doo, Farooq Khokar, Kittichai Promrat, David Herion, Yoon Park, T.Jake Liang, Jay H. Hoofnagle  Gastroenterology  Volume 124, Issue 1, Pages 97-104 (January 2003) DOI: 10.1053/gast.2003.50018 Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 1 Mean rate of worsening scores for fibrosis per year between 2 liver biopsies according to (A) patient age at initial liver biopsy (by every 15 years), (B) initial ALT level (n = 118; by fold elevation above the upper limit of normal), and (C) initial reading for periportal necrosis and inflammation (0–1, no or mild piecemeal necrosis; 3–4, moderate or marked piecemeal necrosis; 5–6, moderate or marked piecemeal necrosis plus bridging necrosis; 10, multilobular necrosis). The Knodell scores for lobular and portal inflammation are not included in this figure; hence, the maximal score is 10 and not 18. Gastroenterology 2003 124, 97-104DOI: (10.1053/gast.2003.50018) Copyright © 2003 American Gastroenterological Association Terms and Conditions