Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE Lars Bertram, Christoph Lange, Kristina.

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Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE Lars Bertram, Christoph Lange, Kristina Mullin, Michele Parkinson, Monica Hsiao, Meghan F. Hogan, Brit M.M. Schjeide, Basavaraj Hooli, Jason DiVito, Iuliana Ionita, Hongyu Jiang, Nan Laird, Thomas Moscarillo, Kari L. Ohlsen, Kathryn Elliott, Xin Wang, Diane Hu- Lince, Marie Ryder, Amy Murphy, Steven L. Wagner, Deborah Blacker, K. David Becker, Rudolph E. Tanzi The American Journal of Human Genetics Volume 83, Issue 5, Pages 623-632 (November 2008) DOI: 10.1016/j.ajhg.2008.10.008 Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 1 Q-Q Plot of Markers Tested in the GWA Screening Phase Distribution of FBAT-GEE p values for all 404,604 SNPs on the 500K array with ≥20 informative families as Q-Q plot depicting observed versus expected p values. The American Journal of Human Genetics 2008 83, 623-632DOI: (10.1016/j.ajhg.2008.10.008) Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 2 Kaplan-Meier Survival Curves for rs11159647 in 500K Screening Sample and Combined Follow-Up Data Set Dotted lines represent carriers of the A/A genotype, broken lines are A/G-carriers, solid lines are G/G-carriers. (A) shows the NIMH sample used in the 500K screen. (B) shows the sample after combining all follow-up samples (NIA, NCRAD, and CAG). The American Journal of Human Genetics 2008 83, 623-632DOI: (10.1016/j.ajhg.2008.10.008) Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 3 Genomic Context of the Chromosome 14q31 Association Signal Linkage disequilibrium structure and location of Genscan Gene predictions (NTSs) in a 500 kb interval encompassing rs11159647 on chromosome 14q31.2. The American Journal of Human Genetics 2008 83, 623-632DOI: (10.1016/j.ajhg.2008.10.008) Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 4 Association Results of Markers within 500 kb of the Chromosome 14q31 Association Signal Distribution of association results of SNPs on the 500K array within ±250 kb of SNP rs11159647 on chromosome 14q31 showing genome-wide significance in the NIMH-CAU sample (FBAT-GEE statistic, additive model). The American Journal of Human Genetics 2008 83, 623-632DOI: (10.1016/j.ajhg.2008.10.008) Copyright © 2008 The American Society of Human Genetics Terms and Conditions