PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection Yasunori IIda, Hiroki.

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PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection Yasunori IIda, Hiroki Tanaka, Tetsumei Urano, Naoki Unno, Hideyuki Shimizu Journal of Vascular Surgery Volume 65, Issue 6, Pages 192S-193S (June 2017) DOI: 10.1016/j.jvs.2017.03.362 Copyright © 2017 Terms and Conditions

Fig A, Representative images of aortic dissection tissue with hematoxylin-eosin staining (HE) and elastica van Gieson staining (EVG) in acute aortic dissection (AAD) tissue accompanied by medial arterial calcification (MAC). B, Representative aortic histology images show localization of proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in a tissue sample from an AAD with MAC. Low-density lipoprotein (LDL) receptor (green), PCSK9 (red), and DAPI (blue) immunostaining. Scale bars = 500 μm (left), and 100 μm (right). C, Comparison of PCSK9 expression in AAD tissues depended on the presence or absence of MAC. Quantification of immunofluorescence staining. Fluorescence intensity of PCSK9 expression was quantitated using Hybrid Cell Count BZ-H2C software. Statistical analysis was performed using unpaired t-test.∗∗P < .001 indicates a statistically significant difference. Journal of Vascular Surgery 2017 65, 192S-193SDOI: (10.1016/j.jvs.2017.03.362) Copyright © 2017 Terms and Conditions

Fig 2 Journal of Vascular Surgery 2017 65, 192S-193SDOI: (10.1016/j.jvs.2017.03.362) Copyright © 2017 Terms and Conditions