Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis  Alfonso Galderisi, MD, Cosimo Giannini, MD, Ram Weiss, MD, Grace Kim, MD, Veronika Shabanova, PhD, Nicola Santoro, MD, Bridget Pierpont, MA, Mary Savoye, RD, Sonia Caprio, MD  The Lancet Child & Adolescent Health  Volume 2, Issue 10, Pages 726-735 (October 2018) DOI: 10.1016/S2352-4642(18)30235-9 Copyright © 2018 Elsevier Ltd Terms and Conditions

Figure 1 Flow of participants through the study OGTT=oral glucose tolerance test. The Lancet Child & Adolescent Health 2018 2, 726-735DOI: (10.1016/S2352-4642(18)30235-9) Copyright © 2018 Elsevier Ltd Terms and Conditions

Figure 2 Changes in insulin-derived indices from baseline to follow-up, by glucose tolerance changes (A) Change from baseline to follow-up in oral disposition index, in adolescents with normal glucose tolerance at baseline (left) and impaired glucose tolerance at baseline (right). (B) Rate of change per year from baseline in insulin-derived indices, in adolescents with normal glucose tolerance at baseline (left) and impaired glucose tolerance at baseline (right). (C) Rate of change per year from baseline in the oral disposition index, by ethnic background, in adolescents with normal glucose tolerance at baseline (left) and impaired glucose tolerance at baseline (right). Datapoints are median and error bars IQR. CPI=C-peptide index. IGT=impaired glucose tolerance. ISI=insulin sensitivity index. NGT=normal glucose tolerance. oDI=oral disposition index. T2D=type 2 diabetes. The Lancet Child & Adolescent Health 2018 2, 726-735DOI: (10.1016/S2352-4642(18)30235-9) Copyright © 2018 Elsevier Ltd Terms and Conditions