Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats Gonzalo Cruz, Ph.D.,

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Presentation transcript:

Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats Gonzalo Cruz, Ph.D., Rafael Barra, Ph.D., Daniel González, D.V.M., Ramón Sotomayor-Zárate, Ph.D., Hernán E. Lara, Ph.D. Fertility and Sterility Volume 98, Issue 5, Pages 1283-1290 (November 2012) DOI: 10.1016/j.fertnstert.2012.07.1060 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The effect of EV exposure at different ages on vaginal opening and cyclic estrual activity. (A) The percentage of rats that reach vaginal opening according to age is shown. An inserted table shows the mean age of vaginal opening of EV-exposed rats compared with control rats. The results are the means ± SEM. aP<.001 vs. control, n = 5 per group. (B) The percentage of rats that recovered normal cyclic estrual activity during the study period is shown. The figure starts at 60 days of age because before this time point all rats in EV-treated groups were acyclic. An inserted table shows the total number of estrual cycles during the period of the study. The results are the means ± SEM. aP<.001 vs. control; bP<.01 vs. EV30; cP<.05 vs. EV30; n = 5 per group. Fertility and Sterility 2012 98, 1283-1290DOI: (10.1016/j.fertnstert.2012.07.1060) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 The effect of EV exposure at different ages on antral follicular development and ovulation. (A) Number of healthy and atretic antral follicles. (B) Number of corpora lutea. (C) Number of cysts. The results are the means ± SEM. aP<.01 vs. control; bP<.01 vs. EV30; cP<.001 vs. EV21; dP<.01 vs. EV7 and EV14; eP<.01 vs. EV14; fP<.05 vs. EV1 and EV7; n = 5 per each group. Fertility and Sterility 2012 98, 1283-1290DOI: (10.1016/j.fertnstert.2012.07.1060) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Photomicrographs of ovarian histology in rats treated at different ages and sacrificed at 180 days of age. Upper row from left to right shows the ovary of a rat treated at 1, at 7 or at 14 days old. Lower row from left to right shows the ovary treated at 21 at 30 days old and the lower right correspond to the ovary of a control rat. Magnification ×16. CL = corpora lutea; CS = cystic structures. Fertility and Sterility 2012 98, 1283-1290DOI: (10.1016/j.fertnstert.2012.07.1060) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions