Volume 79, Issue 8, Pages (April 2011)

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Volume 79, Issue 8, Pages 800-801 (April 2011) Journal Club Kidney International Volume 79, Issue 8, Pages 800-801 (April 2011) DOI: 10.1038/ki.2011.65 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure Histology of F1 mice with different eNOS genotypes (eNOS+/+, eNOS+/−, and eNOS−/−) and Akita mutation. Top: Periodic acid–Schiff stain. Yellow arrow indicates mesangial expansion; white arrows indicate mesangiolysis; yellow arrowhead indicates glomerulosclerosis. Middle: Glomeruli with Masson trichrome stain. Bottom: Transmission electron micrographs. Kidney International 2011 79, 800-801DOI: (10.1038/ki.2011.65) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure On the surface of vascular cells, ENPP1 (the protein encoded by the ectonucleotide pyrophosphatase–phosphodiesterase 1 gene) converts ATP to AMP and pyrophosphate (PPi), and CD73 converts AMP to adenosine and inorganic phosphate (Pi). Pyrophosphate inhibits calcification, tissue-nonspecific alkaline phosphatase (TNAP) degrades pyrophosphate, and adenosine inhibits TNAP. Deficiency of CD73 results in decreased adenosine levels, eliminating the inhibition of TNAP from the pathway either directly or by way of adenosine receptor signaling. Increased TNAP from the pathway activity results in decreased pyrophosphate and increased cell calcification. Kidney International 2011 79, 800-801DOI: (10.1038/ki.2011.65) Copyright © 2011 International Society of Nephrology Terms and Conditions