Basophils and eosinophils in allergic rhinitis

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Presentation transcript:

Basophils and eosinophils in allergic rhinitis Robert M. Naclerio, MD, Fuad M. Baroody, MD, Anne Kagey-Sobotka, PhD, Lawrence M. Lichtenstein, MD Journal of Allergy and Clinical Immunology Volume 94, Issue 6, Pages 1303-1309 (December 1994) DOI: 10.1016/0091-6749(94)90346-8 Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 1 Number of alcian blue–positive cells recovered by combining nasal lavages obtained at different time points before and after allergen provocation. Data are depicted as mean ± SEM of 10 allergic subjects. Abscissa represents different time points of collection: Pre, Cells recovered from three nasal washes performed at baseline before allergen challenge; 2, cells recovered from washes obtained 20 minutes, 1 hour, and 2 hours after allergen challenge; 5, cells recovered from washes obtained 3, 4, and 5 hours after allergen challenge; 8, cells recovered from washes obtained 6, 7 and 8 hours after allergen challenge; 11, cells recovered from washes obtained 9, 10 and 11 hours after allergen challenge. Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 2 Nasal leukocyte histamine release in response to different stimuli. Data are depicted as mean ± SEM of seven experiments. Nasal leukocytes released histamine in a dose-dependent fashion in response to anti-IgE and also responded to N-formyl-methionyl-leucyl-phenylalanine (FMLP). (From Iliopoulos O, Baroody F, Naclerio RM, Bochner BS, Kagey-Sobotka A, Lichtenstein LM, J Immunol 1992;148:2223-8. Copyright 1992, The Journal of Immunology.) Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 3 Coexpression of CD18 on IgE-bearing nasal leukocytes recovered by nasal lavages of allergic volunteers 24 hours after allergen provocation. Coexpression of CD18 was analyzed after initial gating with scatter, and green fluorescence was done to identify uniform population of IgE-bearing cells. Shaded and solid lines delineate areas that represent staining with control and CD18 antibodies, respectively. Region to left of arrow represents 95% of all control events. Data from one experiment are representative of three others. (From Iliopoulos O, Baroody F, Naclerio RM, Bcohner BS, Kagey-Sobotka A, Lichtenstein LM. J Immunol 1992;148:2223-8. Copyright 1992, The Journal of Immunology.) Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 4 Mediator release after nasal allergen challenge of allergic subjects. Data are depicted as mean ± SEM of seven subjects. Challenge protocol is shown on abscissa. Dil, diluent; 10, 100, and 1000; doses of antigen in protein nitrogen units; PW, wash 20 minutes after challenge with highest antigen dose. Dashed line separates early and late reactions. Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 5 Eosinophil count in nasal biopsy specimens from allergic and nonallergic subjects. Data are depicted as mean ± SEM. Ipsi, Specimens obtained at ipsilateral (same) site of allergen challenge in allergic subjects out of season; Contra, specimens obtained from contralateral unchallenged site in same allergic subjects; Diluent, specimens obtained from seasonal allergic subjects out of season, 24 hours after challenge with diluent for allergen extract; Control, specimens from nonallergic subjects 24 hours after ragweed allergen challenge. Asterisk, p < 0.05 versus all other groups. Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions

FIG. 6 Expression of adhesion molecules on nasal vascular endothelium. Data represent percentage of total vessels (identified by staining with von Willebrand factor) that stained positive with each of adhesion molecules studied: VCAM-1, E-selectin, and ICAM-1. Data are depicted as mean ± SEM of 10 allergic subjects (dark bars) and 13 nonallergic control subjects (striped bars). Biopsies were performed 24 hours after allergen provocation in both groups. Asterisk, p < 0.05 when allergic subjects were compared with nonallergic control subjects. Journal of Allergy and Clinical Immunology 1994 94, 1303-1309DOI: (10.1016/0091-6749(94)90346-8) Copyright © 1994 Mosby, Inc. Terms and Conditions