Sensivity Sensivity Sensivity 100-specify 100-specify 100-specify Fig.2 ROC curves for peak serum GH responses to the GHRH-ARG test in the lean population (BMI<25 kg/m²). The arrow indicates the location on the ROC curves of the diagnostic cut-off point that minimizes misclassification of TPHD patients and control subjects. The ROC AUC, accuracy, PPV and negative predictive value (NPV), with confidence intervalls (c.i.), are shown in the box Fig.3 ROC curves for peak serum GH responses to the GHRH-ARG test in the over-weight population (BMI≥25 and <30 kg/m²). Details are as for Fig.2 Fig.4 ROC curves for peak serum GH responses to the GHRH-ARG test in the GHRH-ARG test in the obese population (BMI>30 kg/m²). Details are as for Fig.2 Sensivity Sensivity Sensivity sensivity: 98.7% (c.i.92.9-99.8%) specifity: 83.7% (c.i.78.6-88.0%) ROC AUC: 0.943 (c.i.0.913-0.955) accuracy 87.1 % pos. predictive value:64.4% (c.i.0.55-0.72%) neg. predictive value:99.5% (c.i.0.97-0.99%) sensivity: 96.7% (c.i.93.9-98.6%) specifity: 75.5% (c.i.71.1-79.5%) ROC AUC: 0.922 (c.i.0.898-0.941) accuracy 78.6% pos. predictive value:65.9% (c.i.0.61-0.78%) neg. predictive value:97.9% (c.i.0.85-0.98%) sensivity: 93.5% (c.i.82.1-98.6%) specifity: 78.3% (c.i.67.9-86.6%) ROC AUC: 0.917 (c.i.0.855-0.958) accuracy 83.9 % pos. predictive value:70.5% (c.i.0.60-0.97%) neg. predictive value:95.6% (c.i.0.86-0.97%) 100-specify 100-specify 100-specify Abbildung mod. nach Corneli, 2005