Ovulographic™ Technology Ovulographic™ Folliculogenesis In Vivo™ (FIV™) Data From Home To Healthcare Providers From patients’ Ovulona™ units to a physician’s Ovulograph™ – when needed Posterior Fornix

Ovulograph™ use for abnormal cycle diagnosis Baseline record flanked by two non-baseline records with abnormalities Abnormal = Delayed Ovulation Baseline cycle Abnormal = Short Luteal Phase Re: Delayed ovulation, see What is the mechanism of stress and how does it affect reproduction. Click on slide to go forward, or use navigation buttons in left bottom corner (or keyboard arrow keys) to navigate back and through the 4 slides

Ovulograph™ use example: symptometry Physicians can correlate symptoms with folliculogenesis to facilitate differential diagnosis. Here for PMS/PMDD vs. clinical depression.   The technology enables the input of symptometric and other auxiliary data in synchrony with the folliculogenesis data, which in turn enables the physician to provide a better medical help. This is unprecedented both in terms of providing the longitudinal cyclic profile data, and the correlated auxiliary data needed for effective diagnosis and treatment. (For example, the determination whether the COPE score rise is pre-ovulatory or post-ovulatory is essential for effective diagnosis of PMS/PMDD, currently not available .) Another auxiliary data is the background monitoring for tissue aberration, which will provide an innocuous and widely accessible screen for pathologies such as cervical cancer, significantly improving upon the current Pap smear screening. COPE = Calendar of Premenstrual Experiences Click on slide to go forward, or use navigation buttons in left bottom corner or keyboard arrow keys to navigate back and forth

Ovulona’s diagnostic power will save healthcare costs The absence of the two pre-ovulation peaks anticipates failure to ovulate. Ovulona™ anticipates Luteal Phase Defect (LPD), which too often causes failure to conceive by healthy women of any age Ovulona’s diagnostic power will save healthcare costs This cannot be matched by currently marketed ovulation prediction products