Embryonic asymmetry: The left side gets all the best genes

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Embryonic asymmetry: The left side gets all the best genes Tim King, Nigel A. Brown  Current Biology  Volume 9, Issue 1, Pages R18-R22 (January 1999) DOI: 10.1016/S0960-9822(99)80036-0

Figure 1 The diagram shows proposed interactions leading to asymmetric left–right development in vertebrates. A role for Vg-1 has been shown only in Xenopus; roles for activins, Shh, Ptc and cSR-1 have been demonstrated only in the chick; and roles for Lefty-1, Lefty-2, the activin type IIb receptor (ActRIIb) and Smad-2 have been demonstrated only in the mouse. Only the heart is shown, but Pitx-2 is involved in directing other visceral asymmetries. Arrows represent inductive interactions, bars repression and question marks putative links for which there is no direct evidence at present. Current Biology 1999 9, R18-R22DOI: (10.1016/S0960-9822(99)80036-0)

Figure 2 A model for symmetry-breaking, based on the model in [1]. (a) Cells are polarised relative to the midline (pink plane and arrows), so that a component is present on their medial face only (pink bars). Microtubules (brown) are aligned in cells relative to the anteroposterior and dorsoventral axes. A complex of left–right dynein (red), inversin (purple) and other components (green) normally moves towards the plus end of the microtuble. This results in accumulation of some putative determinant transported by the complex at the lateral face of cells on the right of the midline, but at the medial face of left hand cells, where there can be an interaction with the medial component, triggering the asymmetric cascade. (b) The absence of inversin, as in inv mutants, is postulated to cause the dynein motor to reverse direction, and thus the interaction occurs on the right and laterality is inverted. (c) The absence of left–right dynein, as in iv mutants, prevents transport, so interaction could occur on either side, leading to randomization of laterality. Current Biology 1999 9, R18-R22DOI: (10.1016/S0960-9822(99)80036-0)