Thirty-Day In-Parallel Artificial Lung Testing in Sheep

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Thirty-Day In-Parallel Artificial Lung Testing in Sheep Hitoshi Sato, MD, Candice M. Hall, BS, LVT, Nathan G. Lafayette, BS, Joshua R. Pohlmann, BS, Niru Padiyar, MD, John M. Toomasian, MS, Jonathan W. Haft, MD, Keith E. Cook, PhD The Annals of Thoracic Surgery Volume 84, Issue 4, Pages 1136-1143 (October 2007) DOI: 10.1016/j.athoracsur.2007.05.051 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The MC3 Biolung total artificial lung (TAL) attached to the flank of a sheep. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Mean arterial pressure (mAP, squares) and cardiac output (CO, circles) at baseline (BL) and at days 1 through 30 after total artificial lung attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Artificial lung resistance (circles) and percentage of cardiac output (CO, squares) flowing to the total artificial lung (TAL) for baseline (BL) and at days 1 through 30 post-TAL attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Typical MC3 Biolung after 30 days. Note thrombus formation at the end of the device closest to the inlet and outlet ports. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Total artificial lung (TAL) blood flow (diamonds) and resistance (circles) for a single, representative sheep at baseline (BL) and at days 1 through 30 post-TAL attachment days one through thirty. Data are averaged over 3-day periods. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Counts for platelets (squares) and white blood cells (circles) at baseline (BL) and at days 1 through 30 after total artificial lung attachment. Data are averaged over 3-day periods and presented with the standard deviation. The Annals of Thoracic Surgery 2007 84, 1136-1143DOI: (10.1016/j.athoracsur.2007.05.051) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions