Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling Akimasa Yamashita,

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Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling Akimasa Yamashita, MD, PhD, Abigail K. Hanna, MD, Satoshi Hirata, MD, PhD, Alan Dardik, MD, PhD, Bauer E. Sumpio, MD, PhD Journal of Vascular Surgery Volume 37, Issue 4, Pages 866-873 (April 2003) DOI: 10.1067/mva.2003.130 Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Densitometry of bFGF immunoreactivity in vein grafts at 7 and 21 days. All data were normalized with the data of the PBS group. *P <.01 versus PBS or Ad.LacZ at 7 days. #P <.01 versus PBS or Ad.LacZ at 21 days. Journal of Vascular Surgery 2003 37, 866-873DOI: (10.1067/mva.2003.130) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Representive cross sections of AVGs. A, PBS at 30 minutes. B, Ad.ASbFGF at 30 minutes. C, PBS at 7 days. D, Ad.ASbFGF at 7 days. E, PBS at 21 days. F, Ad.ASbFGF at 21 days. Neointima is represented between arrowheads. (Original magnification, × 200). Journal of Vascular Surgery 2003 37, 866-873DOI: (10.1067/mva.2003.130) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Neointimal thickness in AVGs at 7 and 21 days. Intimal thickness was measured in hematoxylin-eosin stained tissue section with computerized digital morphometry. Results are mean of four experiments. *P <.01 versus PBS or Ad.LacZ group. Journal of Vascular Surgery 2003 37, 866-873DOI: (10.1067/mva.2003.130) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Time course of MAPK activation in vein grafts treated with PBS and Ad.ASbFGF (n = 4). Phospho-MAPK densitometry data are normalized to total MAPK and to baseline activity in normal vein. In all three MAPK groups, differences between PBS and Ad.ASBFGF groups are significant at both day 4 (P <.01) and day 7 (P <.05). Representative Western blot data demonstrating time course of activated MAPKs are given adjacent to each graph. Journal of Vascular Surgery 2003 37, 866-873DOI: (10.1067/mva.2003.130) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 5 Representive cross sections of AVGs stained for phosphorylated ERK. A, PBS at 7 days. B, PBS at 21 days. Neointima is represented between white arrowheads. Phospho-ERK- positive cells are represented with black arrows. (Original magnification, × 200). Journal of Vascular Surgery 2003 37, 866-873DOI: (10.1067/mva.2003.130) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions