Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms Anastasia Tsigkou,

Slides:

Advertisements

Similar presentations

Charles J. Glueck, M. D. , Joel Pranikoff, M. D. , Dawit Aregawi, M. D

Advertisements

Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature Maria.

International Committee for Monitoring Assisted Reproductive Technology (ICMART) world report: assisted reproductive technology 2003 Karl G. Nygren,

Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity Cristian O'Flaherty, Ph.D., Barbara.

Yuqian Cui, M. D. , Ph. D. , Yuhua Shi, M. D. , Ph. D. , Linlin Cui, M

International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2005 Fernando Zegers-Hochschild,

Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata Yuh-Ming Hwu, M.D., Sheng-Hsiang Li, Ph.D.,

Christine Jablonski, M. D. , Marco Alifano, M. D

The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition Lorraine Dennerstein,

Infertility evaluation and treatment among women in the United States

Fernando Zegers-Hochschild, M.D. Fertility and Sterility

Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients Hong-Yuan.

Michael M. Alper, M.D. Fertility and Sterility

Association of physical activity in the past year and immediately after in vitro fertilization on pregnancy Kelly R. Evenson, Ph.D., M.S., Kathryn C.

Dennis J. Hand, Ph. D. , Vanessa L. Short, Ph. D. , M. P. H. , Diane J

Qi Shen, M. D. , Ying Hua, M. D. , Ph. D. , Wenxiao Jiang, M. D

Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata

Ethnicity as a determinant of ovarian reserve: differences in ovarian aging between Spanish and Indian women Carlos Iglesias, M.D., Manish Banker, M.D.,

Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study Nicole Hope, M.B., B.S., Hon., Luk.

Endometrial stromal progesterone receptor-A/progesterone receptor-B ratio: no difference between women with and without endometriosis Davide Gentilini,

Panagiotis Bakas, M. D. , Angelos Liapis, M. D

Iris G. Insogna, M. D. , Malinda S. Lee, M. D. , M. B. A. , Rebecca M

How old is too old? Challenges faced by clinicians concerning age cutoffs for patients undergoing in vitro fertilization Robert L. Klitzman, M.D. Fertility.

Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation Paola Montagna, B.Sc., Silvia.

Impact of submucous myoma on the severity of anemia

Trends in clinical reproductive medicine research: 10 years of growth

Wen-Ling Lee, M. D. , Wei-Min Liu, M. D. , Jong-Ling Fuh, M. D

The role of steroid hormone supplementation in non–assisted reproductive technology treatments for unexplained infertility Alexander M. Quaas, M.D.,

Transurethral partial cystectomy and laparoscopic reconstruction for the management of bladder endometriosis See-Tong Pang, M.D., Ph.D., Angel Chao,

Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity Beth W. Rackow, M.D., Hugh S. Taylor, M.D. Fertility.

Nonclassic 21-hydroxylase deficiency presenting as endometrial hyperplasia with uterine bleeding in a 67-year-old woman Marguerite B. Vigliani, M.D.,

With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice? Jacques Donnez, M.D., Ph.D., Olivier.

Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth.

Gadolinium radiologic contrast is a useful alternative for hysterosalpingography in patients with iodine allergy Dorette Noorhasan, M.D., Michael J.

Parasitic myomas after laparoscopic myomectomy: case report

Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development Mark Payson, M.D., Minnie Malik,

Xiuye Xing, M. D. , Ph. D. , Han Zhao, M. D. , Ph. D. , Mei Li, M. Sc

Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study Li Wei, Ph.D., Thomas MacDonald, M.D.,

A meta-analysis of the route of administration of luteal phase support in assisted reproductive technology: vaginal versus intramuscular progesterone

Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature Maria.

Randomized controlled trial comparing embryo culture in two incubator systems: G185 K-System versus EmbryoScope Julie Barberet, Pharm.D., Jérémy Chammas,

Rodrigo Borsari, M. D. , Nilo Bozzini, Ph. D

Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors José Bellver, M.D., Antonio.

Modulation of HOXA10 and other markers of endometrial receptivity by age and human chorionic gonadotropin in an endometrial explant model Robin H. Fogle,

Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-

Aimee S. Browne, M. D. , M. Sc. , Jie Yu, M. D. , M. Sc

Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration Ewa Barcz,

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Pietro Santulli, M. D. , Bruno Borghese, M. D. , Ph. D

Granulosa–lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in in vitro fertilization (IVF) cycles: relation to.

Masaaki Iwahashi, M.D., Yasuteru Muragaki, M.D.

Jichan Nie, Yuan Lu, M. D. , Ph. D. , Xishi Liu, M. D. , Ph. D

Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism Shun-An.

Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor Jason D. Parker, D.O., Minnie.

Lin Mu, Ph. D. , Wei Zheng, Ph. D. , M. D. , Liang Wang, Ph. D

Low serum and peritoneal fluid concentration of interferon-γ–induced protein-10 (CXCL10) in women with endometriosis Letizia Galleri, Ph.D., Stefano.

High serum concentration of total inhibin in polycystic ovary syndrome

Fertility and Sterility: an evaluation

Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss Lia A. Bernardi, M.D., Ronald N. Cohen, M.D., Mary D. Stephenson, M.D.,

International Committee for Monitoring Assisted Reproductive Technologies: World Report on Assisted Reproductive Technologies, 2007 Osamu Ishihara, M.D.,

Current evaluation of amenorrhea

Genetic evaluation procedures at sperm banks in the United States

Aline Ketefian, M. D. , Jianfang Hu, Ph. D. , Alfred A. Bartolucci, Ph

Kostis Gyftopoulos, M. D. , Ph. D. , Christina Chondrogianni, M. Sc

Jason Yen-Ping Ho, M. D. , Weng Chi Man, Ph. D. , Yan Wen, M. D

MicroRNA-22-3p is down-regulated in the plasma of Han Chinese patients with premature ovarian failure Yujie Dang, M.D., Ph.D., Shidou Zhao, Ph.D., Yingying.

Altered circulating levels of matrix metalloproteinases 2 and 9 and their inhibitors and effect of progesterone supplementation in women with endometriosis.

Endometrial polyps affect uterine receptivity

The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review.

Decreasing bleeding due to uterine fibroid with electroacupuncture

Presentation transcript:

Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms Anastasia Tsigkou, Ph.D., Fernando M. Reis, M.D., Meng H. Lee, Ph.D., Bingjie Jiang, Ph.D., Claudia Tosti, M.D., Gabriele Centini, M.D., Fang-Rong Shen, M.D., You-Guo Chen, M.D., Felice Petraglia, M.D. Fertility and Sterility Volume 104, Issue 1, Pages 170-175.e1 (July 2015) DOI: 10.1016/j.fertnstert.2015.04.024 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Relative mRNA expression of the progesterone receptors, (A) PR-total and (B) PR-B, and protein levels of (C) PR-A and (D) PR-B in paired samples of human myometrium and uterine leiomyoma. M = molecular weight marker. Data are expressed as median and interquartile range. *P<.05, Wilcoxon test. Fertility and Sterility 2015 104, 170-175.e1DOI: (10.1016/j.fertnstert.2015.04.024) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Relative mRNA expression of progesterone receptor (PR) total and PR-B in leiomyoma samples from women classified according to the number of myomas and age. *P<.05; **P<.01, Mann-Whitney U test. The bottom picture shows Western blot bands of PR-A and PR-B in leiomyoma samples from women up to 40 years old with one to three myomas (lanes 1–2) and women over 40 years-old with more than three myomas (lanes 3–6). Fertility and Sterility 2015 104, 170-175.e1DOI: (10.1016/j.fertnstert.2015.04.024) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Nonparametric correlation plots of progesterone receptor B (PR-B) mRNA expression with patient's age (A), number of leiomyomas (B), dysmenorrhea (C), and intermenstrual bleeding (D). r = Spearman's rank correlation coefficient. Fertility and Sterility 2015 104, 170-175.e1DOI: (10.1016/j.fertnstert.2015.04.024) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions