The first self-endothelialized titanium-coated glutaraldehyde-fixed heart valve prosthesis within systemic circulation Norbert W. Guldner, MD, Inka Jasmund,

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Presentation transcript:

The first self-endothelialized titanium-coated glutaraldehyde-fixed heart valve prosthesis within systemic circulation Norbert W. Guldner, MD, Inka Jasmund, MS, Hanngörg Zimmermann, MS, Markus Heinlein, MS, Britta Girndt, MS, Martin Großherr, MD, Mathias Klinger, MD, Hans H. Sievers, MD The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 1, Pages 248-250 (July 2009) DOI: 10.1016/j.jtcvs.2008.11.045 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Valve topography within the inflow and outflow part of the pumping chamber of a biomechanical heart, a muscular blood pump within the aorto–aortic position. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 248-250DOI: (10.1016/j.jtcvs.2008.11.045) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Porcine detoxified and titanized aortic valve, having been implanted heterotopically within the aorta of a goat for 6 months, is in good condition (A). Cross section of a valve leaflet (B) shows recellularization of the blood-contacting surface (hematoxylin–eosin stain, magnification 20×). Immunhistochemic staining against von Willebrand factor proves endothelialization of the blood-contacting surface, labeled with alkaline phosphatase (C) and visualized with immunofluorescence (D). The Journal of Thoracic and Cardiovascular Surgery 2009 138, 248-250DOI: (10.1016/j.jtcvs.2008.11.045) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions