Estimated Glomerular Filtration Rate Within the Normal or Mildly Impaired Range and Incident Cardiovascular Disease Alon Eisen, MD, Moshe Hoshen, PhD,

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Estimated Glomerular Filtration Rate Within the Normal or Mildly Impaired Range and Incident Cardiovascular Disease Alon Eisen, MD, Moshe Hoshen, PhD, Ran D. Balicer, MD, PhD, MPH, Orna Reges, PhD, Yardena Rabi, BIMS, Morton Leibowitz, MD, Zaza Iakobishvili, MD, PhD, David Hasdai, MD The American Journal of Medicine Volume 128, Issue 9, Pages 1015-1022.e2 (September 2015) DOI: 10.1016/j.amjmed.2015.03.024 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Distribution of eGFR (estimated glomerular filtration rate) values among the study population according to (A) Chronic Kidney Disease EPIdemiology collaboration (CKD-EPI) (n = 1,341,000) and (B) Modification of Diet in Renal Disease (MDRD) (n = 1,284,762) formulas. The American Journal of Medicine 2015 128, 1015-1022.e2DOI: (10.1016/j.amjmed.2015.03.024) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Age-adjusted odds ratios (95% confidence interval) for the occurrence of incident cardiovascular disease based on estimated glomerular filtration rate (eGFR), as assessed by the Chronic Kidney Disease EPIdemiology collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) formulas. (eGFR values are in deciles, with 60 mL/min/1.73 m2 < eGFR ≤ 70 mL/min/1.73 m2 as the reference range). The American Journal of Medicine 2015 128, 1015-1022.e2DOI: (10.1016/j.amjmed.2015.03.024) Copyright © 2015 Elsevier Inc. Terms and Conditions

Supplementary Figure Study design. CHS = Clalit Health Services; CKD-EPI = Chronic Kidney Disease EPIdemiology collaboration; CVD = cardiovascular disease; eGFR = estimated glomerular filtration rate; MDRD = Modification of Diet in Renal Disease. The American Journal of Medicine 2015 128, 1015-1022.e2DOI: (10.1016/j.amjmed.2015.03.024) Copyright © 2015 Elsevier Inc. Terms and Conditions