Conspiracy Theory Cell

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Presentation transcript:

Conspiracy Theory Cell Paul W Sternberg, José Alberola-Ila Cell Volume 95, Issue 4, Pages 447-450 (November 1998) DOI: 10.1016/S0092-8674(00)81612-8

Figure 1 Model of SUR-8/SOC-2 and CNK in RTK to MAP Kinase Signaling A generic pathway of signal transduction from a receptor tyrosine kinase to MAP kinase. Arrows indicate catalysis: GDP release in the case of SOS; phosphorylation in the cases of RTK, RAF, MEK, and MAP kinase. Cell 1998 95, 447-450DOI: (10.1016/S0092-8674(00)81612-8)

Figure 2 Different Types of RTK Adaptors Receptor tyrosine kinases are known to recruit GRB2·SOS in three ways: receptor autophosphorylation and binding of GRB2·SOS; via an intermediate adaptor such as Shc, which binds GRB2·SOS once it is recruited to the RTK; or phosphorylation of membrane-localized proteins such as FRS-2, LAT, and possibly DOF. Cell 1998 95, 447-450DOI: (10.1016/S0092-8674(00)81612-8)