Harding H. Luan, Ruslan Medzhitov Cell Metabolism

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Presentation transcript:

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense Harding H. Luan, Ruslan Medzhitov Cell Metabolism Volume 24, Issue 3, Pages 379-387 (September 2016) DOI: 10.1016/j.cmet.2016.08.013 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Role of Itaconate in the Immune Response (A) IRG1/CAD is induced upon inflammation and converts cis-aconitate to itaconate. Itaconate has direct antimicrobial effects on both intracellular bacteria and extracellular bacteria. Additionally, itaconate can inhibit succinate dehydrogenase activity, leading to decreased ROS production and inflammation. (B) IRG1/CAD decarboxylates cis-aconitate to generate itaconate. Cell Metabolism 2016 24, 379-387DOI: (10.1016/j.cmet.2016.08.013) Copyright © 2016 Elsevier Inc. Terms and Conditions