Predictors of new fragility fractures after diagnosis of indolent systemic mastocytosis Eveline van der Veer, PhD, Suzanne Arends, PhD, Sjoukje van der.

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Presentation transcript:

Predictors of new fragility fractures after diagnosis of indolent systemic mastocytosis Eveline van der Veer, PhD, Suzanne Arends, PhD, Sjoukje van der Hoek, BSc, Joris B. Versluijs, BSc, Jan G.R. de Monchy, MD, PhD, Joanna N.G. Oude Elberink, MD, PhD, Jasper J. van Doormaal, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 6, Pages 1413-1421 (December 2014) DOI: 10.1016/j.jaci.2014.05.003 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flowchart of handling of fracture data from patients with ISM. Journal of Allergy and Clinical Immunology 2014 134, 1413-1421DOI: (10.1016/j.jaci.2014.05.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Lifetime FFxs in patients before and/or after the diagnosis of ISM. A, All patients with ISM (n = 221). B, Patients with ISM used for the predictor analysis (n = 181). Journal of Allergy and Clinical Immunology 2014 134, 1413-1421DOI: (10.1016/j.jaci.2014.05.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 FFx-free survival curves of the 5 independent predictors: male sex, sCTX Z-score of +1.0 or greater, hip BMD T-score of −1.0 or less, absence of UP, and use of alcohol. Journal of Allergy and Clinical Immunology 2014 134, 1413-1421DOI: (10.1016/j.jaci.2014.05.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 FFx-free survival curves per MastFx score (0-5) using a prediction model consisting of 5 patient characteristics. Journal of Allergy and Clinical Immunology 2014 134, 1413-1421DOI: (10.1016/j.jaci.2014.05.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions