Martin K. Kuhlmann, Martina Heckmann, Werner Riegel, Hans Köhler

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Evaluation of renal Kt/V as a marker of renal function in predialysis patients Martin K. Kuhlmann, Martina Heckmann, Werner Riegel, Hans Köhler Kidney International Volume 60, Issue 4, Pages 1540-1546 (October 2001) DOI: 10.1046/j.1523-1755.2001.00957.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Relationship of measured renal Kt/V to serum creatinine (SCr) concentration. (A) Within the complete data set (N = 465 measurements in 125 patients). (B) In predialysis patients defined by renal Kt/V (rKt/V) <2.50 per week (N = 116 measurements in 42 patients). Kidney International 2001 60, 1540-1546DOI: (10.1046/j.1523-1755.2001.00957.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Relationship of measured creatinine (CCr) and urea (CUr) clearances and transformations of serum creatinine (SCr) concentration to measured renal Kt/V in predialysis patients (N = 116). Predialysis stage of advanced renal disease was defined by r-Kt/V <2.5 per week. Solid lines represent regression lines, Pearson correlation coefficients are indicated on the bottom of each graph. (A) Creatinine clearance estimated from Cockcroft-Gault formula (CCG, P = NS). (B) GFR estimated from MDRD equation 6 (MDRD6-GFR, P = 0.0026). (C) Measured creatinine clearance (CCr, P < 0.0001); (D) Measured urea clearance (CUr, P < 0.0001); (E) Average of measured creatinine and urea clearance (CCr/Ur, P < 0.0001). Kidney International 2001 60, 1540-1546DOI: (10.1046/j.1523-1755.2001.00957.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Effect of variations in urea distribution volume (UDV) on renal Kt/V under the condition of stable urea clearance. Data for a hypothetical patient with a stable urea clearance of 7.0mL/min are depicted. The horizontal dotted line represents r-Kt/V = 2.0 per week as threshold for dialysis initiation, the vertical dotted line indicates UDV of 35L at which r-Kt/V equals 2.0 per week. Kidney International 2001 60, 1540-1546DOI: (10.1046/j.1523-1755.2001.00957.x) Copyright © 2001 International Society of Nephrology Terms and Conditions