Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfaces E. Teeple, M.D., B.C. Fleming, Ph.D.,

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Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfaces E. Teeple, M.D., B.C. Fleming, Ph.D., A.P. Mechrefe, M.D., J.J. Crisco, Ph.D., M.F. Brady, B.S., G.D. Jay, M.D., Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 3, Pages 309-315 (March 2007) DOI: 10.1016/j.joca.2006.08.011 Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 A schematic of the pendulum apparatus is shown. The guinea pig knee joint served as the fulcrum. Osteoarthritis and Cartilage 2007 15, 309-315DOI: (10.1016/j.joca.2006.08.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Sample output showing the decay response of the pendulum following the initial 17° rotation about the F–E axis (θpeak) applied to the pendulum. Osteoarthritis and Cartilage 2007 15, 309-315DOI: (10.1016/j.joca.2006.08.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Mean peak F–E rotation angle vs oscillation before and after treatment for the saline (A) and α-chymotrypsin (B) treated knees. The error bars represent ±1 standard deviation. Osteoarthritis and Cartilage 2007 15, 309-315DOI: (10.1016/j.joca.2006.08.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Trichrome staining indicates that the presence of surface damage in the α-chymotrypsin-treated knee but not the saline-treated knee: (A) saline-treated distal femur, (B) enzyme-treated distal femur, (C) saline-treated proximal tibia, (D) enzyme-treated proximal tibia. Note that the lamina splendens is thinner and more fragmented in the sections from the α-chymotrypsin knee. Osteoarthritis and Cartilage 2007 15, 309-315DOI: (10.1016/j.joca.2006.08.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Safranin-O/fast green (tibial cartilage shown here) indicates no difference in proteoglycan content following treatment with either (A) saline or (B) α-chymotrypsin. Osteoarthritis and Cartilage 2007 15, 309-315DOI: (10.1016/j.joca.2006.08.011) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions