Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver- derived angiotensinogen  David I. Ortiz-Melo, Robert F. Spurney  Kidney International  Volume 85, Issue 5, Pages 1009-1011 (May 2014) DOI: 10.1038/ki.2013.440 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 A defect in glomerular permselectivity enhances renal angiotensin II generation. Loss of glomerular filtration barrier integrity permits significant amounts of angiotensinogen and renin into the tubular fluid. With angiotensin-converting enzyme present on the proximal tubule brush border, all the components required for robust angiotensin II generation are present in the tubular lumen. ACE, angiotensin-converting enzyme; AGT, angiotensinogen; Ang II, angiotensin II; AT1R, Ang II type 1 receptor. Kidney International 2014 85, 1009-1011DOI: (10.1038/ki.2013.440) Copyright © 2014 International Society of Nephrology Terms and Conditions