On a Randomization Procedure in Linkage Analysis

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Presentation transcript:

On a Randomization Procedure in Linkage Analysis Hongyu Zhao, Kathleen R. Merikangas, Kenneth K. Kidd  The American Journal of Human Genetics  Volume 65, Issue 5, Pages 1449-1456 (November 1999) DOI: 10.1086/302607 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Overall Z scores calculated with GENEHUNTER (ZGH), GENEHUNTER-PLUS (ZP), and the randomization procedure (ZR), at six markers on chromosome 3, for the simulated data from GAW10 problem 2A. A total of 576 pedigrees with two or more affected individuals each were analyzed. The American Journal of Human Genetics 1999 65, 1449-1456DOI: (10.1086/302607) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Overall Z scores calculated with GENEHUNTER (ZGH), GENEHUNTER-PLUS (ZP), and the randomization procedure (ZR), at seven markers on chromosome 5, for the simulated data from GAW10 problem 2A. A total of 576 pedigrees with two or more affected individuals each were analyzed. The American Journal of Human Genetics 1999 65, 1449-1456DOI: (10.1086/302607) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 3 Observed overall Z scores calculated with GENEHUNTER (ZGH), GENEHUNTER-PLUS (ZP), and the randomization procedure (ZR), at 11 markers on the long arm of chromosome 6. A total of 285 U.K. diabetes pedigrees were analyzed. The American Journal of Human Genetics 1999 65, 1449-1456DOI: (10.1086/302607) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

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