aSIRTing Control over Cancer Stem Cells

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aSIRTing Control over Cancer Stem Cells Takahiro Ito, Bryan Zimdahl, Tannishtha Reya Cancer Cell Volume 21, Issue 2, Pages 140-142 (February 2012) DOI: 10.1016/j.ccr.2012.01.014 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 SIRT1 Inhibition Effectively Targets CML Cancer Stem Cells Chronic myelogenous leukemia (CML) is composed of differentiated cells (blue and purple) as well as a more primitive pool of cancer stem cells (red) that have the capacity to propagate the disease (left). The kinase inhibitor Imatinib can eliminate differentiated CML cells but cannot effectively target cancer stem cells (middle). Though insensitive to Imatinib, cancer stem cells remain dependent on SIRT1. Thus, the combined use of the SIRT1 inhibitor Tenovin 6 and Imatinib effectively removes residual cancer stem cells and may block CML at its root (right). Cancer Cell 2012 21, 140-142DOI: (10.1016/j.ccr.2012.01.014) Copyright © 2012 Elsevier Inc. Terms and Conditions