Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors Shixiong Liao, MSa, Manuel.

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Presentation transcript:

Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors Shixiong Liao, MSa, Manuel Miralles, MDa, Brian J. Kelley, BAa, John A. Curci, MDa, Martin Borhani, MDa, Robert W. Thompson, MDa, b, c Journal of Vascular Surgery Volume 33, Issue 5, Pages 1057-1064 (May 2001) DOI: 10.1067/mva.2001.112810 Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Development of elastase-induced abdominal aortic aneurysms in the rat. AD measurements after transient perfusion with either saline or elastase are expressed as percent increase between preperfusion and final AD. Each bar represents mean ± SEM for six rats. AAAs (horizontal line ) consistently developed within 7 days of elastase perfusion and were uniformly present by day 14. *P <.05 vs day 0, Student t test. Journal of Vascular Surgery 2001 33, 1057-1064DOI: (10.1067/mva.2001.112810) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Effect of ACE inhibitors on the development of elastase-induced AAAs. Aneurysmal dilatation was assessed 14 days after elastase perfusion in animals treated with water alone or water supplemented with 250 mg/L of either captopril (CP ), lisinopril (LP ), enalapril (EP ), or losartan (LOS). Each bar represents mean ± SEM for six rats, with AAAs (horizontal line ). *P <.05, compared with water-treated controls. Journal of Vascular Surgery 2001 33, 1057-1064DOI: (10.1067/mva.2001.112810) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Effect of ACE inhibitors on histology of elastase-induced AAAs. Transverse sections of formalin-fixed aortic tissue were stained with Verhoeff-van Gieson stain for elastin. a, Normal preperfusion aorta. b, Fourteen days after perfusion with saline, no aneurysmal dilatation. c, Fourteen days after perfusion with elastase, marked aneurysmal dilatation. d, Fourteen days after perfusion with elastase and captopril (CP ) treatment, no aneurysmal dilatation. Elastase-induced AAAs were associated with chronic inflammation and destruction of medial elastin (short arrows ). Treatment with ACE inhibitors was associated with preservation of elastic lamellae (long arrow ; original magnification, 100×). Journal of Vascular Surgery 2001 33, 1057-1064DOI: (10.1067/mva.2001.112810) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Comparison of ACE inhibitors, aortic dilatation versus hemodynamic effects. Effects of different agents on elastase-induced aortic dilatation at day 14 are compared with their effects on mean arterial BP, with abdominal aortic aneurysms (AAA s) indicated (horizontal line ). There was no significant correlation demonstrated, r = 0.28), indicating that ACE inhibitors suppress aneurysmal degeneration by a mechanism(s) independent of their hemodynamic effects. Journal of Vascular Surgery 2001 33, 1057-1064DOI: (10.1067/mva.2001.112810) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions