Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and.

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Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis A.M. Valdes, I. Meulenbelt, E. Chassaing, N.K. Arden, S. Bierma-Zeinstra, D. Hart, A. Hofman, M. Karsdal, M. Kloppenburg, H.M. Kroon, E.P. Slagboom, T.D. Spector, A.G. Uitterlinden, J.B. van Meurs, A.C. Bay-Jensen Osteoarthritis and Cartilage Volume 22, Issue 5, Pages 683-689 (May 2014) DOI: 10.1016/j.joca.2014.02.007 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Forest plot of study-specific estimates and summary OR estimates and 95% confidence intervals (95%CIs) for the association between (A) serum COMP and prevalence of knee OA (B) urinary CTX2 and prevalence of knee OA. fe summary = fixed effects summary statistic, re summary = random effects summary statistic. The inter-study heterogeneity I2 is shown along with the corresponding significance level for each fixed effects estimate. The statistical significance for fixed and random effects summary statistics is also shown. Osteoarthritis and Cartilage 2014 22, 683-689DOI: (10.1016/j.joca.2014.02.007) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Forest plot of study-specific estimates and fixed effects summary OR estimates and 95% confidence intervals (95%CIs) for the association between urinary CTXII and (A) prevalence of hand OA (B) prevalence of hip OA (C) radiographic severity of knee OA (D) progression of knee OA. fe summary = fixed effects summary statistic, re summary = random effects summary statistic. The inter-study heterogeneity I2 is shown along with the corresponding significance level for each fixed effects estimate. The statistical significance for fixed and random effects summary statistics is also shown. Osteoarthritis and Cartilage 2014 22, 683-689DOI: (10.1016/j.joca.2014.02.007) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions