Nitric Oxide Synthase and Adenylyl and Guanylyl Cyclase Activity in Porcine Interposition Vein Grafts Jamie Y Jeremy, PhD, Michael R Dashwood, PhD, Maureen.

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Nitric Oxide Synthase and Adenylyl and Guanylyl Cyclase Activity in Porcine Interposition Vein Grafts Jamie Y Jeremy, PhD, Michael R Dashwood, PhD, Maureen Timm, BSc, Mohammad Bashar Izzat, FRCS, Dheeraj Mehta, FRCS, Alan J Bryan, FRCS, Gianni D Angelini, FRCS The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 470-476 (February 1997) DOI: 10.1016/S0003-4975(96)01144-7

Fig. 1 Prostaglandin E1 [PGE1]–stimulated cyclic adenosine monophosphate (cAMP) synthesis by porcine ungrafted saphenous vein (▴), carotid artery (circles), and saphenous vein graft (diamonds). Each point = mean ± standard error of the mean (n = 8). (#p < 0.05, saphenous vein graft versus ungrafted saphenous vein and carotid artery.) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)

Fig. 2 Forskolin-stimulated cyclic adenosine monophosphate (cAMP) synthesis by porcine ungrafted saphenous vein (triangles), carotid artery (circles), and saphenous vein graft (diamonds). Each point = mean ± standard error of the mean (n = 8). (#p < 0.05, saphenous vein graft versus ungrafted saphenous vein and carotid artery.) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)

Fig. 3 Nitroprusside-stimulated cyclic guanosine monophosphate (cGMP) synthesis by porcine ungrafted saphenous vein (triangles), carotid artery (circles), and saphenous vein graft (diamonds). Each point = mean ± standard error of the mean (n = 8). (black star = p < 0.05 [saphenous vein graft versus ungrafted saphenous vein]; #p < 0.05 [ungrafted saphenous vein versus carotid artery]; white star = p < 0.05 [saphenous vein graft versus carotid artery].) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)

Fig. 4 A23187-stimulated cyclic guanosine monophosphate (cGMP) synthesis by porcine ungrafted saphenous vein (triangles), carotid artery (circles), and saphenous vein graft (diamonds). Each point = mean ± standard error of the mean (n = 8). (black star = p < 0.05 [saphenous vein graft versus ungrafted saphenous vein]; # = p < 0.05 [ungrafted saphenous vein versus carotid artery]; white star = p < 0.05 [saphenous vein graft versus carotid artery].) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)

Fig. 5 Fig. 5. [3H]l-NG-nitroarginine binding (low resolution) to porcine ungrafted saphenous vein (SV), carotid artery (CC), and vein graft (VG). Autoradiographs, generated on film, from sections incubated in 10-nmol/L 3Hl-NG-nitroarginine alone (total binding [TOT]). Nonspecific binding (NSB) was established in the presence of 10 μmol/L l-arginine. Middle panel shows hematoxylin and eosin–stained sections underlying the autoradiographs. (Scale bar = 2.5 mm.) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)

Fig. 6 Representative autoradiographs generated on nuclear emulsion (dark-field illumination, where white grains represent binding sites [left panels]]) of binding to sections of porcine ungrafted saphenous vein (SV), carotid artery (CC), and vein graft (VG) incubated in 10-nmol/L [3H]l-NG-nitroarginine alone. Photomicrographs in righthand panels are of hematoxylin and eosin–stained sections underlying total autoradiographs. The relative density of [3H]l-NG-nitroarginine binding determined by grain counting (carotid artery > vein graft > ungrafted saphenous vein) corresponds to A23187-stimulated cyclic guanosine monophosphate synthesis (see Fig. 4). (Scale bar = 2.5 μm; TM = tunica media; L = lumen.) The Annals of Thoracic Surgery 1997 63, 470-476DOI: (10.1016/S0003-4975(96)01144-7)