Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches Emily J. Swindle, PhD, Jane E. Collins,

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Presentation transcript:

Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches Emily J. Swindle, PhD, Jane E. Collins, PhD, Donna E. Davies, PhD Journal of Allergy and Clinical Immunology Volume 124, Issue 1, Pages 23-34 (July 2009) DOI: 10.1016/j.jaci.2009.05.037 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Schematic outline of bronchial epithelium showing basal (b), goblet (g), and columnar (c) cells and its interrelationship with cells of the immune system. Immunofluorescent staining of ZO-1 shows the location of TJs between cells forming the physical barrier (top left). The transmission electron micrograph on the right shows bronchial epithelium with goblet cell (g), columnar cell (c), basal cell (b), lamina reticularis (lr), and a MC (m). Above is a schematic depiction of some of the proteins identified in TJ complexes. Not shown are tricellulin and ZO-3. Tricellulin occurs in tricellular TJs (ie, where 3 epithelial cells meet), and its localization is supported by occludin.37 The ZO proteins bind directly to occludin at the submembranous region of the junction. This interaction is mediated in ZO-1 and ZO-2 by their COOH terminal region, and a similar association is expected for ZO-3.38 7H6, A 155 kDa phosphoprotein antigen; JAM, junctional Adhesion Molecule; Eos, eosinophil. Journal of Allergy and Clinical Immunology 2009 124, 23-34DOI: (10.1016/j.jaci.2009.05.037) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions