A Rare Central Thoracic Tumor

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Presentation transcript:

A Rare Central Thoracic Tumor Kristof Cuppens, MD, Marion Delcroix, MD, PhD, Dirk Van Raemdonck, MD, PhD, Bart Meyns, MD, PhD, Rafael Sciot, MD, PhD, Maria Debiec-Rychter, MD, PhD, Johan F. Vansteenkiste, MD, PhD Journal of Thoracic Oncology Volume 9, Issue 6, Pages 897-899 (June 2014) DOI: 10.1097/JTO.0000000000000162 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Transaxial chest computed tomography images (A) show a mass invading the right pulmonary artery and mediastinum and a central filling defect in the proximal left pulmonary artery (arrow). The mass had moderate 18F-fluorodeoxyglucose uptake on positron emission tomography (B). Journal of Thoracic Oncology 2014 9, 897-899DOI: (10.1097/JTO.0000000000000162) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Resection specimen showing tumor occluding the right pulmonary artery (A) and a pale pulmonary artery cast after left pulmonary endarterectomy (B). Journal of Thoracic Oncology 2014 9, 897-899DOI: (10.1097/JTO.0000000000000162) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Histopathological examination. Low power view (A) showing the tumor nodules in the arterial branches (arrows), and at higher magnification (B), a moderately cellular spindle cell proliferation is present. Immunohistochemistry showing nuclear MDM2 expression (C) and strong cytoplasmic epidermal growth factor receptor labeling (D). Journal of Thoracic Oncology 2014 9, 897-899DOI: (10.1097/JTO.0000000000000162) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions