Neurodegeneration of the Substantia Nigra after Ipsilateral Infarct: MRI R2* Mapping and Relationship to Clinical Outcome Substantia nigra R2* was higher.

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Presentation transcript:

Neurodegeneration of the Substantia Nigra after Ipsilateral Infarct: MRI R2* Mapping and Relationship to Clinical Outcome Substantia nigra R2* was higher at 1 year if ipsilateral striatum was infarcted than if not infarcted (P < .001). R2* mapping may be added to the follow-up MRI after stroke to monitor neurodegeneration by assessing iron deposition in the substantia nigra. R2* maps of the substantia nigra may indicate asymmetry of iron deposition, which in turn correlates with worse long-term motor function. Voxel-based lesion-symptom mapping confirmed that striatum, insula, internal capsule, and external capsule were associated with higher R2* at 1 year of follow up. Linck PA et al. Published Online: Mar 12, 2019 https://doi.org/10.1148/radiol.2019182126