Role of myocardial hypertrophy on acute and chronic right ventricular performance in relation to chronic volume overload in a porcine model: Relevance.

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Presentation transcript:

Role of myocardial hypertrophy on acute and chronic right ventricular performance in relation to chronic volume overload in a porcine model: Relevance for the surgical management of tetralogy of Fallot Thierry Bove, MD, Kristof Vandekerckhove, MD, Stefaan Bouchez, MD, Patrick Wouters, MD, PhD, Pamela Somers, MSc, PhD, Guido Van Nooten, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 6, Pages 1956-1965 (June 2014) DOI: 10.1016/j.jtcvs.2013.10.026 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Time course and conduct of the study, defining the surgical procedure and right ventricular function assessment at phases 1 and 2. PAB, Pulmonary artery banding; TAP, transannular patch; RVOT, right ventricular outflow tract; Echo, echocardiography. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1956-1965DOI: (10.1016/j.jtcvs.2013.10.026) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Baseline pressure–volume loop of right ventricle in pig in the right ventricular hypertrophy and pulmonary insufficiency group, showing the method of pulmonary regurgitation (PR) fraction calculation (PR volume/stroke volume × 100). The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1956-1965DOI: (10.1016/j.jtcvs.2013.10.026) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A, Bar plot of Emax derived from end-systolic pressure–volume relationship at both study phases. *P < .05 between the pulmonary insufficiency (PI) group and the sham and right ventricular hypertrophy (RVH) groups; §P < .05 between the RVH+PI group and sham and RVH groups. B, Bar plot of Mw derived from preload recruitable stroke work at both study phases. *P < .05 between the PI group and sham and RVH groups; **P < .05 between the PI group and all other groups; §P < .05 between the RVH+PI group and sham and RVH groups. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1956-1965DOI: (10.1016/j.jtcvs.2013.10.026) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Bar plot of β-stiffness coefficient derived from end-diastolic pressure–volume relationship at both study phases. #P < .05 between the right ventricular hypertrophy (RVH) and RVH plus pulmonary insufficiency (PI) groups and sham and PI groups. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1956-1965DOI: (10.1016/j.jtcvs.2013.10.026) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions