Nonspecific interstitial pneumonia fibrosing pattern in a case of connective tissue disease. a) The alveolar walls are thickened by interstitial fibrosis.

Slides:



Advertisements
Similar presentations
Management of Myositis-Related Interstitial Lung Disease
Advertisements

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.
Pathological alterations in idiopathic pulmonary fibrosis (IPF).
Changes in high-resolution computed tomography (HRCT) pattern over time. a) Idiopathic pulmonary fibrosis (IPF), increased specificity over time. Changes.
Longitudinal imaging after initial diagnosis
Pathological changes in chronic obstructive pulmonary disease
Immunostaining for lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) adduct in the lungs of smokers with and without chronic obstructive pulmonary.
Radiology assessment of pulmonary amyloidosis
In chronic haemorrhage a) several pigmented macrophages fill the alveoli with dense fibrosis of the interstitium; b) the haemosiderin pigment in macrophages.
Flowchart showing the requirement for starting, documenting and evaluating the effect on quality of life (QoL) of interdisciplinary best supportive care.
A) Axial computed tomography (CT) showing mild thickening of bronchial walls (arrows) in a woman with Sjögren's syndrome. b) Chronic cough and recurrent.
High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.
a) Chest radiograph showing bilateral coarse interstitial shadowing
Nonspecific interstitial pneumonia in a woman a, c) at the time of Sjögren's syndrome diagnosis and b) after 3 years. a, b) High-resolution computed tomography.
A) Usual interstitial pneumonia in a 69-year-old woman with primary Sjögren's syndrome. a) Usual interstitial pneumonia in a 69-year-old woman with primary.
Representative photomicrograph of small airways abnormalities in a subject with chronic obstructive pulmonary disease. Representative photomicrograph of.
A) Low magnification histopathological biopsy showing typical features of usual interstitial pneumonia pattern with a heterogeneous appearance and areas.
Smoking cessation rate as point prevalence quit rate from year 1 to 5 in the Lung Health Study with 5,587 chronic obstructive pulmonary disease patients.
A–c) This lung biopsy from a 55-year-old male patient, who was a nonsmoker, shows a typical desquamative interstitial pneumonia pattern. a–c) This lung.
Representative photomicrographs of individual bronchiolar lesions observed in surgical lung biopsy in patients with small airways disease. a) Cellular.
Smoking-related fibrosis with dense acellular fibrosis that frequently surrounds cystic emphysematous spaces, both in a) centrilobular (haematoxylin and.
Prevalence of chronic bronchitis in relation to active smoking, stratified by age. □: nonsmokers; ▒: 1–10 cigarettes per day; ░: 11–20 cigarettes per day;
Unclassifiable interstitial fibrosis.
3-year survival of lung cancer patients in the general population and in those with a prior diagnosis of chronic obstructive pulmonary disease (COPD).
Pattern high-resolution computed tomography consistent with nonspecific interstitial pneumonia in a patient with histological diagnosis of usual interstitial.
Evaluation of acute symptoms
A summary of the pathogenesis, pathophysiology and clinical implications of the pulmonary vascular and cardiac abnormalities in interstitial lung disease.
A) Respiratory bronchiolitis: the intra-alveolar accumulation of finely pigmented macrophages (smoker’s macrophages) (haematoxylin and eosin, 400×). a)
Time to disease progression or death in a) the whole Bosentan Use in Interstitial Lung Disease (BUILD)-1 study population and b) the subpopulation with.
Evaluation of complications.
Usual interstitial pneumonia pattern on histopathology showing alternation of fibrosing areas and a) normal/subnormal parenchymal areas and b) fibroblastic.
Simplified diagram of the multidisciplinary process to diagnose interstitial lung disease, including a clinician, radiologist, pathologist and also a geneticist:
Morphological subtypes of cyst-related primary lung malignancies
High-resolution computed tomography scan of a 59-year-old female patient with undifferentiated connective tissue disease, showing patterns of nonspecific.
Incidence of chronic obstructive pulmonary disease according to the history of chronic cough/phlegm. Incidence of chronic obstructive pulmonary disease.
A) High-resolution computed tomography shows innumerable ill-defined centrilobular ground-glass opacity nodules, characteristic of sub-acute hypersensitivity.
Outline of the distal lung regions in haematoxylin and eosin-stained lung tissue [115, 116] showing the inner airway wall (green arrowheads), smooth muscle.
Transbronchial cryobiopsy (TBCx)
The alveolar compartment in idiopathic pulmonary fibrosis (IPF).
A) 8-isoprostane levels in exhaled breath condensate in smokers with chronic obstructive pulmonary disease (COPD). *: p
This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis.
Example of thin parenchymal section computed tomography findings in desquamative interstitial pneumonia: patchy ground-glass attenuation with a peripheral.
Survival of idiopathic pulmonary arterial hypertension (IPAH) patients in World Health Organization functional class (FC) at baseline IV is extremely poor.
Chronic hypersensitivity pneumonitis with usual interstitial pneumonia pattern. a) At low magnification, bronchiolar damage with bridging fibrosis between.
A) Small pulmonary arteries within a fibrotic area (usual interstitial pneumonia lung). a) Small pulmonary arteries within a fibrotic area (usual interstitial.
A) Axial and b) coronal computed tomography scans of usual interstitial pneumonia pattern in a patient with rheumatoid arthritis. a) Axial and b) coronal.
Effect of pulmonary arterial hypertension (PAH) on SF-36-measured health-related quality of life (HRQoL) measures versus the normal population and other.
Proportion of participants with access to a, b) a radiologist and c, d) a pathologist experienced in interstitial lung diseases to discuss cases of suspected.
Comorbidities/associated conditions/complications assessed in patients diagnosed with idiopathic pulmonary fibrosis (IPF) in the 2013 Advancing IPF Research.
Usual interstitial pneumonia pattern in two patients with idiopathic pulmonary fibrosis. a) At low magnification, subpleural/paraseptal scars obscuring.
High-resolution computed tomography with nonspecific interstitial pneumonia pattern in a patient with connective tissue disease; bilateral reticulation.
Schematic diagram of the shared subgroups between asthma and chronic obstructive pulmonary disease (COPD). Schematic diagram of the shared subgroups between.
Use of high-resolution computed tomography imaging to diagnose different connective tissue disease-associated interstitial lung diseases (ILDs), and to.
Correlation between inspiratory capacity (IC)/total lung capacity (TLC) ratio and oxygen pulse at peak exercise in chronic obstructive pulmonary disease.
Apart from their well-established presence in the conducting airways, mast cells in the human respiratory system are also abundant in other key compartments.
Procedure for the diagnosis of interstitial lung diseases.
Examples of “classical” small airway disease in severe asthma from video-assisted thoracoscopic surgery procured tissue showing small airways with epithelial.
High-resolution computed tomography from a patient with anti-Jo1 positive polymyositis showing basilar predominate reticulation and ground-glass opacity.
Distribution and change of the underlying disease in patients discharged with home mechanical ventilation (n = 854). ♦: chronic obstructive pulmonary disease;
Cellular players and molecules in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease. Cellular players and.
Possible mechanisms of famillial idiopathic interstitial pneumonia leading to lung fibrosis involves apoptosis caused mainly through chronic endoplasmic.
Hyperplastic alveolar epithelial type II cells show severe endoplasmic reticulum stress and consecutive apoptosis. Hyperplastic alveolar epithelial type.
Open lung biopsy specimen showing an inflammation with thickened interalveolar septa and the inflammatory infiltration of mononuclear cells (areas of a.
Evidence-based indications for noninvasive positive-pressure ventilation (NPPV) according to the severity and time of acute respiratory failure (ARF) [18].
Schematic of the relationship between smoking and legume consumption (smoking–diet relationship) in relation to pulmonary inflammation, systemic inflammation,
High-resolution computed tomography scan demonstrating a typical example of usual interstitial pneumonia pattern with honeycombing change and traction.
Diagnostic algorithm for idiopathic pulmonary fibrosis (IPF).
High-resolution computed tomography images of smoking-related interstitial lung diseases (ILDs). a) Pulmonary Langerhans cell histiocytosis, b) respiratory.
A) Mucosa-associated lymphoid tissue lymphoma in a 45-year-old woman with primary Sjögren's syndrome. a) Mucosa-associated lymphoid tissue lymphoma in.
A) Smokers’ macrophages show a fine, golden haemosiderin cytoplasmic pigment; b) in respiratory bronchiolitis (RB), smokers’ macrophages are located in.
Presentation transcript:

Nonspecific interstitial pneumonia fibrosing pattern in a case of connective tissue disease. a) The alveolar walls are thickened by interstitial fibrosis and chronic inflammation. b) Hyperplasia of the lymphoid tissue is present. Nonspecific interstitial pneumonia fibrosing pattern in a case of connective tissue disease. a) The alveolar walls are thickened by interstitial fibrosis and chronic inflammation. b) Hyperplasia of the lymphoid tissue is present. S. Harari, and A. Caminati Eur Respir Rev 2010;19:97-108 ©2010 by European Respiratory Society