Perioperative monitoring of platelet function in paediatric cardiac surgery by thromboelastometry, or platelet aggregometry?†   B.S. Romlin, F Söderlund, H Wåhlander, S Hallhagen, C Wessman, F Baghaei, A Jeppsson  British Journal of Anaesthesia  Volume 116, Issue 6, Pages 822-828 (June 2016) DOI: 10.1093/bja/aew053 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Receiver operating characteristic (ROC) curves for the accuracy of MCF (a) and CFT (b) in detecting adenosine diphosphate-dependent platelet dysfunction during cardiopulmonary bypass. The area under the curve was 0.886 for MCF and 0.863 for CFT. CFT, clot formation time; MCF, maximal clot firmness. British Journal of Anaesthesia 2016 116, 822-828DOI: (10.1093/bja/aew053) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 ADP-, AA-, and TRAP-induced platelet aggregation during CPB in children with MCF ≤43 mm or >43 mm (a), in children with CFT ≥166 s or <166 s (b), and in children with both, one, or none of CFT ≥166 s and MCF ≤43 mm (c). AA, arachidonic acid; ADP, adenosine diphosphate; CFT, clot formation time, MCF, maximum clot firmness; TRAP, thrombin receptor-activating peptide. In panel A denotes **P<0.01 and ***P<0.001 vs MCF ≤43 mm; (b) ***P<0.001 vs CFT ≥166 s; (c) *P<0.05, **P<0.01 and ***P>0.001 vs MCF ≤43 mm and CFT ≥166 s, and #P<0.05 and ##P<0.01 vs MCF ≤43 mm or CFT ≥166 s. British Journal of Anaesthesia 2016 116, 822-828DOI: (10.1093/bja/aew053) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 Prevalence of intraoperative transfusions in children with MCF ≤43 mm or >43 mm (a) in children with CFT ≥166 s or <166 s (b) and in children with both, one, or none of CFT ≥166 s and MCF ≤43 mm (c). CFT, clot formation time; MCF, maximum clot firmness. (a) **P<0.01 vs MCF ≤43 mm; (c) *P<0.05, **P<0.01 vs MCF ≤43 mm and CFT ≥166 s. British Journal of Anaesthesia 2016 116, 822-828DOI: (10.1093/bja/aew053) Copyright © 2016 The Author(s) Terms and Conditions