Intensity Dependent Effects of Transcranial Direct Current Stimulation on Corticospinal Excitability in Chronic Spinal Cord Injury Lynda M. Murray, PhD,

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Intensity Dependent Effects of Transcranial Direct Current Stimulation on Corticospinal Excitability in Chronic Spinal Cord Injury Lynda M. Murray, PhD, Dylan J. Edwards, PhD, Giulio Ruffini, PhD, Douglas Labar, MD, PhD, Argyrios Stampas, MD, Alvaro Pascual- Leone, MD, PhD, Mar Cortes, MD Archives of Physical Medicine and Rehabilitation Volume 96, Issue 4, Pages S114-S121 (April 2015) DOI: 10.1016/j.apmr.2014.11.004 Copyright © 2015 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 Study design schematic. During the first visit, initial evaluations (UEMS, AIS) and questionnaires (SCIM III, VAS) were completed. During the 20-minute intervention period, participants received either 1 or 2mA of a-tDCS or sham. Neurophysiology and muscle strength measures were recorded at 3 time points (pre, post, follow-up). Abbreviation: SCIM III, Spinal Cord Independence Measure version III. Archives of Physical Medicine and Rehabilitation 2015 96, S114-S121DOI: (10.1016/j.apmr.2014.11.004) Copyright © 2015 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 2 Electric field (normative component) generated by the montage (+C3, -AF8) using Pi electrodes (3.14cm2 silver/silver chloride electrodes). Positive/negative values indicate anodal/cathodal stimulation (normative component of the electric field pointing inward/outward at the cortical surface). Archives of Physical Medicine and Rehabilitation 2015 96, S114-S121DOI: (10.1016/j.apmr.2014.11.004) Copyright © 2015 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 3 Normalized MEP amplitude changes over time (N=9). Values are presented as mean ± SE. ∗Significant difference (P=.001). Archives of Physical Medicine and Rehabilitation 2015 96, S114-S121DOI: (10.1016/j.apmr.2014.11.004) Copyright © 2015 American Congress of Rehabilitation Medicine Terms and Conditions