L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis James J. DiNicolantonio, PharmD, Carl J. Lavie,

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Presentation transcript:

L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis James J. DiNicolantonio, PharmD, Carl J. Lavie, MD, Hassan Fares, MD, Arthur R. Menezes, MD, James H. O'Keefe, MD Mayo Clinic Proceedings Volume 88, Issue 6, Pages 544-551 (June 2013) DOI: 10.1016/j.mayocp.2013.02.007 Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Process for selecting included trials. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Forest plot of odds ratios for all-cause mortality. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Forest plot of risk ratios for ventricular arrhythmia. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 4 Forest plot of risk ratios for myocardial reinfarction. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 5 Forest plot of risk ratios for the development of HF. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 6 Forest plot of risk ratios for the development of angina. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 7 Forest plot of risk ratios for all-cause mortality including and excluding small studies. IV = inverse variance. Mayo Clinic Proceedings 2013 88, 544-551DOI: (10.1016/j.mayocp.2013.02.007) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions