Cellular therapy reverses myocardial dysfunction

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Cellular therapy reverses myocardial dysfunction C. Rajnoch, MSc, J.-C. Chachques, MD, PhD, A. Berrebi, MD, P. Bruneval, MD, M.-O. Benoit, MD, A. Carpentier, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 121, Issue 5, Pages 871-878 (May 2001) DOI: 10.1067/mtc.2001.112937 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig 1 Cardiac troponin I levels measured in sheep serum 2 hours preoperatively until 6 days after a left ventricular cardiotoxin injection or sodium chloride as a control. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 871-878DOI: (10.1067/mtc.2001.112937) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig 2 A , Well-defined transmural lesion produced by a cardiotoxin injection into the myocardium of a sheep. B, Microscopic section of the myocardial lesion stained with Masson trichrome showing cardiomyocytes (c) on the periphery and fibrous tissue (green) and adipocytes (a) in the lesion (magnification × 10). C, Echocardiography with color kinesis showing few color overlays in the akinetic region (arrow) of the left ventricular anterior wall in a 3-week-old myocardial lesion. D, Increase in color overlays representing an improved segmental contraction (arrow) in the same sheep 2 months after cell implantation. The Journal of Thoracic and Cardiovascular Surgery 2001 121, 871-878DOI: (10.1067/mtc.2001.112937) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig 3 Serial sections of injured sheep myocardium showing implanted skeletal muscle cells (red) stained with (A) skeletal fast MHC antibodies, (B) hematein and eosin staining, and (C) Masson trichrome staining indicating cell survival in fibrous tissue (green). Adipocytes (A) were present inside the lesion and cardiomyocytes (C) were noted on the periphery of the lesion. D, The implanted satellite cells were also found as elongated structures resembling myotubes (magnifications × 10). The Journal of Thoracic and Cardiovascular Surgery 2001 121, 871-878DOI: (10.1067/mtc.2001.112937) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions