Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children Marla C. Dubinsky, Subra Kugathasan, Ling Mei, Yoana Picornell,

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Presentation transcript:

Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children Marla C. Dubinsky, Subra Kugathasan, Ling Mei, Yoana Picornell, Justin Nebel, Iwona Wrobel, Antonio Quiros, Gary Silber, Ghassan Wahbeh, Lirona Katzir, Eric Vasiliauskas, Ron Bahar, Anthony Otley, David Mack, Jonathan Evans, Joel Rosh, Maria Oliva Hemker, Neal Leleiko, Wallace Crandall, Christine Langton, Carol Landers, Kent D. Taylor, Stephan R. Targan, Jerome I. Rotter, James Markowitz, Jeffrey Hyams Clinical Gastroenterology and Hepatology Volume 6, Issue 10, Pages 1105-1111 (October 2008) DOI: 10.1016/j.cgh.2008.04.032 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 (A) Frequency of NPNS, IP/S, and surgery among the different antibody sum groups. P trend <.0001. (B) Frequency of NPNS, IP, S, and surgery among the different quartile sum score groups; P trend <.0001. Clinical Gastroenterology and Hepatology 2008 6, 1105-1111DOI: (10.1016/j.cgh.2008.04.032) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 (A) Survival estimates for IP/S by antibody sum 0, vs 1, vs 2, vs 3 (prospective patients only); P < .0001. (B) Survival estimates for CD-related surgery by antibody sum 0, vs 1, vs 2, vs 3 (prospective patients only); P < .0001. (C) Survival estimates for IP/S by quartile sum score (QSS) group 1, vs 2, vs 3, vs 4 (prospective patients only); P < .0001. (D) Survival estimates for CD-related surgery by QSS group 1, vs 2, vs 3, vs 4 (prospective patients only); P < .0001. Clinical Gastroenterology and Hepatology 2008 6, 1105-1111DOI: (10.1016/j.cgh.2008.04.032) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 (A) Survival estimates for IP/S by antibody sum 0, vs 1, vs 2, vs 3 (all patients); P < .0001. (B) Survival estimates for IP/S by quartile sum score (QSS) group 1, vs 2, vs 3, vs 4 (all patients); P < .0001. Clinical Gastroenterology and Hepatology 2008 6, 1105-1111DOI: (10.1016/j.cgh.2008.04.032) Copyright © 2008 AGA Institute Terms and Conditions