Volume 156, Issue 1, Pages e5 (January 2019)

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Volume 156, Issue 1, Pages 88-95.e5 (January 2019) Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis Rohit Loomba, Arun J. Sanyal, Kris V. Kowdley, Norah Terrault, Naga P. Chalasani, Manal F. Abdelmalek, Arthur J. McCullough, Reshma Shringarpure, Beatrice Ferguson, Lois Lee, Jianfen Chen, Alexander Liberman, David Shapiro, Brent A. Neuschwander-Tetri Gastroenterology Volume 156, Issue 1, Pages 88-95.e5 (January 2019) DOI: 10.1053/j.gastro.2018.09.021 Copyright © 2019 AGA Institute Terms and Conditions

Figure 1 Forest plot of predictors of histologic response. Plot shows the odds ratio and 95% CIs for each of the selected predictors of responses. If the odds ratio is >1, the predictor is associated with higher odds of histologic response. Significance of each of the selected predictors was assessed using a Wald chi-squared test. Gastroenterology 2019 156, 88-95.e5DOI: (10.1053/j.gastro.2018.09.021) Copyright © 2019 AGA Institute Terms and Conditions

Figure 2 ROC curves. The ROC curve for the overall population (N = 200) is shown in red, the ROC curve for patients receiving OCA (n = 102) is shown in purple, and the ROC curve for patients receiving placebo (n = 98) is shown in black. The model was significant when applied to the overall population, as well as to each of the treatment groups (P < .0001 for all). Gastroenterology 2019 156, 88-95.e5DOI: (10.1053/j.gastro.2018.09.021) Copyright © 2019 AGA Institute Terms and Conditions

Figure 3 Scatterplot of model predictions. Scatterplot shows the probability of histologic response and accuracy of each prediction for all patients assessed in this analysis. Gastroenterology 2019 156, 88-95.e5DOI: (10.1053/j.gastro.2018.09.021) Copyright © 2019 AGA Institute Terms and Conditions

Supplementary Figure 1 Model development. The jackknife method systematically removes 1 observation (patient) at a time and reassesses the entire model. Gastroenterology 2019 156, 88-95.e5DOI: (10.1053/j.gastro.2018.09.021) Copyright © 2019 AGA Institute Terms and Conditions