Morphologic characteristics of varicose veins: possible role of metalloproteinases Kenneth J Woodside, MD, Mingdao Hu, MD, Ann Burke, MS, Maki Murakami,

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Presentation transcript:

Morphologic characteristics of varicose veins: possible role of metalloproteinases Kenneth J Woodside, MD, Mingdao Hu, MD, Ann Burke, MS, Maki Murakami, MD, Lori L Pounds, MD, Lois A Killewich, MD, PhD, John A Daller, MD, PhD, Glenn C Hunter, MD Journal of Vascular Surgery Volume 38, Issue 1, Pages 162-169 (July 2003) DOI: 10.1016/S0741-5214(03)00134-4

Fig 1 Western blotting demonstrates expression of MMP-1, MMP-2, MMP-9, MMP-12, TIMP-1, and TIMP-2 protein in normal and varicose veins in 10 patients. Journal of Vascular Surgery 2003 38, 162-169DOI: (10.1016/S0741-5214(03)00134-4)

Fig 2 Zymography demonstrates MMP-2, MMP-9, and MMP-12 activity in normal and varicose veins. Journal of Vascular Surgery 2003 38, 162-169DOI: (10.1016/S0741-5214(03)00134-4)

Fig 3 Histochemical staining of section of normal saphenous vein (A) and varicose vein (B) shows disorganization of intimal and medial connective tissue elements in the varicose vein (hematoxylin-eosin; original magnification ×100). Pentachrome staining of normal vein (C) and varicose vein (D) demonstrates normal (black arrow) and attenuated (white arrow) regions of varicose vein wall (pentachrome; original magnification ×40). Elastic tissue stained black, muscle stained maroon, and extracellular matrix stained yellow. High-power view shows well-organized components of the wall of a normal vein (E) and disorganization in a varicose vein (F), with an area of intimal thickening (arrow) (pentachrome; original magnification ×200). Journal of Vascular Surgery 2003 38, 162-169DOI: (10.1016/S0741-5214(03)00134-4)

Fig 4 Immunohistochemical staining (DAB ×200) of representative sections of normal and varicose vein for matrix metalloproteinase (MMP). Brown-staining endothelial cells (SMC) and microvessels (arrows) expressing MMP-1 in normal vein (A), compared with more diffuse staining in varicose vein (B). Absence of staining for MMP-2 in both normal (C) and varicose (D) veins. Brown-staining adventitial microvessels (black arrows), SMC (white arrow), and endothelium (arrowhead) express MMP-9 in normal vein (E) and varicose vein (F) vein. Brown-staining SMC and fibroblasts express MMP-12 in normal vein (G) and varicose vein (H). Journal of Vascular Surgery 2003 38, 162-169DOI: (10.1016/S0741-5214(03)00134-4)

Fig 5 Immunohistochemical staining (DAB ×200) of representative sections of normal and varicose vein for tissue inhibitor of metalloproteinase (TIMP)–1 (A, B) and TIMP-2 (C, D) demonstrates absence of detectable protein expression. Journal of Vascular Surgery 2003 38, 162-169DOI: (10.1016/S0741-5214(03)00134-4)