Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis

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Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis Dominique Guyader, Christian Jacquelinet, Romain Moirand, Bruno Turlin, Michel H. Mendler, Jacques Chaperon, Véronique David, Pierre Brissot, Paul Adams, Yves Deugnier Gastroenterology Volume 115, Issue 4, Pages 929-936 (October 1998) DOI: 10.1016/S0016-5085(98)70265-3 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Representation of the distribution of variables: 50% of values are comprised within the box (between the 25th and 75th percentile), and the horizontal bar gives the median; 80% of values are comprised between the extremities of vertical bars (between the 10th and 90th percentile), and the extreme values are represented as individual points. 2, No severe fibrosis; ▨, severe fibrosis. Gastroenterology 1998 115, 929-936DOI: (10.1016/S0016-5085(98)70265-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Correlation between serum ferritin and AST values. Spearman test: ρ = 0.628; P < 10−4. The horizontal and vertical bars represent the chosen thresholds for serum ferritin = 1000 μg/L and AST = 1 ULN. Gastroenterology 1998 115, 929-936DOI: (10.1016/S0016-5085(98)70265-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 3 Decision tree using the three variables (serum ferritin, hepatomegaly, and serum AST) selected by multivariate analysis. The term fibrosis refers to severe (stage 3 or 4) fibrosis. Gastroenterology 1998 115, 929-936DOI: (10.1016/S0016-5085(98)70265-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 4 Validation of the clinical predictive model in the Canadian population. The term fibrosis refers to severe (stage 3 or 4) fibrosis. Gastroenterology 1998 115, 929-936DOI: (10.1016/S0016-5085(98)70265-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions